The Flavonoid Quercetin Modulates the Hallmark Capabilities of Hamster Buccal Pouch Tumors.
Epidemiological studies have consistently demonstrated the protective effects of dietary phytochemicals against cancer risk. Quercetin, a ubiquitous dietary flavonoid, has attracted considerable attention owing to its potent antioxidant and antiproliferative activities. The present study was designe...
| Publicado en: | Nutrition & Cancer Vol. 63; no. 2; pp. 218 - 227 |
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| Autores principales: | , , , , |
| Formato: | clinical trial pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104820651&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104820651 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2011 vid: 63 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104820651 58529365 10.1080/01635581.2011.523503 NLM21294050 104820651 ppf: 218 ppct: 9 formats: fmt: @attributes: type: P tig: atl: The Flavonoid Quercetin Modulates the Hallmark Capabilities of Hamster Buccal Pouch Tumors. aug: au: Priyadarsini, Ramamurthi Vidya Vinothini, Govindarajah Murugan, Ramalingam Senthil Manikandan, Palrasu Nagini, Siddavaram affil: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Tamil Nadu, India sug: subj: Quercetin Therapeutic Use Mouth Neoplasms Diagnosis Animal Studies Hamsters Flavonoids Therapeutic Use Mouth Mucosa Genotype Male Clinical Trials Immunohistochemistry Proteins Physiology Electrophoresis Methods Blotting, Western DNA, Recombinant Data Analysis Methods Descriptive Statistics T-Tests Fisher's Exact Test Analysis of Variance Male ab: Epidemiological studies have consistently demonstrated the protective effects of dietary phytochemicals against cancer risk. Quercetin, a ubiquitous dietary flavonoid, has attracted considerable attention owing to its potent antioxidant and antiproliferative activities. The present study was designed to investigate the chemopreventive as well as the therapeutic ability of quercetin to modulate the key hallmark capabilities of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinomas. We analyzed the expression of markers associated with cell proliferation and survival (PCNA, p21, p53, cyclin D1, GST-P), apoptosis (Fas, Fas-L, Bcl-2 family proteins, cytochrome-C, Apaf-1, caspases, PARP, survivin, cFLIP, API1), invasion (MMPs, TIMP-2, RECK), angiogenesis (PlGF, VEGF, VEGF receptors, HIF-1α), as well as the epigenetic markers (HDAC-1, DNMT1) by immunohistochemical, Western blot, and RT-PCR analyses. Simultaneous administration of quercetin to DMBA-painted hamsters reduced tumor incidence and tumor burden, while posttreatment of quercetin resulted in a significant tumor growth delay. In addition, quercetin administration induced cell cycle arrest and apoptosis and blocked invasion and angiogenesis. We found a positive correlation between the inhibition of HDAC-1 and DNMT1 by quercetin and its anticancer properties. A dietary phytochemical such as quercetin that modulates a plethora of molecules offers promise as an ideal candidate for multitargeted cancer prevention and therapy. pubtype: Academic Journal doctype: clinical trial pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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