Hypofractionation results in reduced tumor cell kill compared to conventional fractionation for tumors with regions of hypoxia.

Purpose: Tumor hypoxia has been observed in many human cancers and is associated with treatment failure in radiation therapy. The purpose of this study is to quantify the effect of different radiation fractionation schemes on tumor cell killing, assuming a realistic distribution of tumor oxygenation...

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Bibliographic Details

Published in:	International Journal of Radiation Oncology, Biology, Physics Vol. 79; no. 4; pp. 1188 - 1196
Main Authors:	Carlson DJ, Keall PJ, Loo BW Jr, Chen ZJ, Brown JM, Carlson, David J, Keall, Paul J, Loo, Billy W Jr, Chen, Zhe J, Brown, J Martin
Format:	research Journal Article
Published:	Pergamon Press - An Imprint of Elsevier Science Mar2011
Online Access:	View this record in EBSCOhost