An MEG study of alpha modulation in patients with schizophrenia and in subjects at high risk of developing psychosis.
Background: Selective attention involves a dynamic interaction between attentional control systems and brain oscillations. In auditory processing, selective attention toward task-relevant stimuli and the inhibition of irrelevant information can be considered as aspects of top-down attentional contro...
| Published in: | Schizophrenia Research Vol. 126; no. 1-3; pp. 36 - 43 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Elsevier B.V.
Mar2011
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104835182&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104835182 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09209964 3PT jtl: Schizophrenia Research issn: 09209964 maglogo: N pubinfo: dt: Mar2011 vid: 126 iid: 1-3 pid: 1004 pub: Elsevier B.V. artinfo: ui: 104835182 NLM21036541 2010967596 10.1016/j.schres.2010.10.001 NLM21036541 104835182 ppf: 36 ppct: 7 formats: tig: atl: An MEG study of alpha modulation in patients with schizophrenia and in subjects at high risk of developing psychosis. aug: au: Koh Y Shin KS Kim JS Choi JS Kang DH Jang JH Cho KH O'Donnell BF Chung CK Kwon JS Koh, Yuri Shin, Kyung Soon Kim, June Sic Choi, Jung-Seok Kang, Do-Hyung Jang, Joon Hwan Cho, Kwang-Hyun O'Donnell, Brian F Chung, Chun Kee Kwon, Jun Soo affil: Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC, Seoul, Republic of Korea sug: subj: Brain Mapping Evoked Potentials, Auditory Physiology Diagnosis, Neurologic Psychotic Disorders Physiopathology Schizophrenia Physiopathology Acoustic Stimulation Methods Adult Analysis of Variance Case Control Studies Electroencephalography Female Human Male Neuropsychological Tests Psychological Tests Spectrum Analysis Time Factors Young Adult Adult: 19-44 years Female Male ab: Background: Selective attention involves a dynamic interaction between attentional control systems and brain oscillations. In auditory processing, selective attention toward task-relevant stimuli and the inhibition of irrelevant information can be considered as aspects of top-down attentional control. Oscillatory rhythms in the alpha band have been found to play an important role during top-down processing. Because attention deficits have been noted in patients with schizophrenia, we examined alpha oscillations in schizophrenia and in the prodromal phase of psychosis.Methods: The present study compared alpha oscillations using measures of both spectral power and inter-trial coherence in 17 subjects at ultra-high-risk, 10 patients with schizophrenia, and 18 matched normal control subjects. Whole-head magnetoencephalography (MEG) was conducted during an auditory oddball task to investigate alpha brain activity related to selective attention to target stimuli and selective inhibition of irrelevant stimuli.Results: Patients with schizophrenia showed diminished alpha event-related desynchronization compared with the control subjects, while the ultra-high-risk subjects had values intermediate between the control subjects and schizophrenia patients. Similarly, alpha inter-trial phase coherence was lower in the schizophrenia patients than the ultra-high-risk subjects, and lower in the ultra-high-risk subjects than the normal control subjects. Furthermore, alpha band activity in the parieto-occipital region was more severely depressed in the schizophrenia patients than the ultra-high-risk subjects.Conclusions: The altered alpha band activity in the ultra-high-risk group indicates that a deficit in top-down attentional control exists before the onset of psychosis. The alpha event-related desynchronization and inter-trial coherence may reflect a functional decline in the prodromal phase of schizophrenia. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|