Development and validation of a prediction model for the risk of developing febrile neutropenia in the first cycle of chemotherapy among elderly patients with breast, lung, colorectal, and prostate cancer.
Purpose: Current guidelines recommend prophylactic use of granulocyte-colony stimulating factors (G-CSF) when febrile neutropenia (FN) risk is greater than 20%. Advanced age is a risk factor for FN; however, little is known about the impact of other factors on the incidence of FN in an older populat...
| Publicado en: | Supportive Care in Cancer Vol. 19; no. 3; pp. 333 - 342 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104835215&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104835215 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Mar2011 vid: 19 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104835215 58696951 NLM20179995 2010967630 10.1007/s00520-010-0821-1 NLM20179995 PMC3046362 104835215 ppf: 333 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Development and validation of a prediction model for the risk of developing febrile neutropenia in the first cycle of chemotherapy among elderly patients with breast, lung, colorectal, and prostate cancer. aug: au: Hosmer W Malin J Wong M Hosmer, Wylie Malin, Jennifer Wong, Mitchell affil: David Geffen School of Medicine at UCLA, Los Angeles, CA, USA sug: subj: Antineoplastic Agents Adverse Effects Fever Chemically Induced Models, Biological Neutropenia Chemically Induced Febrile Neutropenia Aged Aged, 80 and Over Antineoplastic Agents Therapeutic Use Female Fever Prevention and Control Forecasting Granulocyte Colony-Stimulating Factor Therapeutic Use Human Male Multivariate Analysis Neoplasm Staging Neoplasms Drug Therapy Neoplasms Pathology Neutropenia Prevention and Control Practice Guidelines Risk Factors Registries, Disease Aged: 65+ years Aged, 80 & over Female Male ab: Purpose: Current guidelines recommend prophylactic use of granulocyte-colony stimulating factors (G-CSF) when febrile neutropenia (FN) risk is greater than 20%. Advanced age is a risk factor for FN; however, little is known about the impact of other factors on the incidence of FN in an older population.Patients and Methods: We analyzed SEER-Medicare data (1994-2005) to develop and validate a prediction model for hospitalization with fever, infection, or neutropenia occurring after chemotherapy initiation for patients with breast, colorectal, prostate, and lung cancer.Results: In multivariate analysis (N = 58,053) independent predictors of FN included advanced stage at diagnosis [stage 2 (OR 1.29; 95% CI: 1.09-1.53), stage 3 (1.38; 95% CI: 1.19-1.60), and stage 4 (1.57; 95% CI: 1.35-1.83)], number of associated comorbid conditions [one condition (1.13; 95% CI: 1.02-1.28), two conditions (1.39; 95% CI: 1.22-1.57), and three or more conditions (1.81; 95% CI: 1.61-2.04)], receipt of myelosuppressive chemotherapy (1.11; 95% CI: 0.94-1.32), and receipt of chemotherapy within 1 month of diagnosis [1 to 3 months (0.70; 95% CI: 0.62-0.80) and greater than 3 months (0.63; 95% CI: 0.55-0.73)].Conclusion: We created a prediction model for febrile neutropenia with first cycle of chemotherapy in a large population of elderly patients with common malignancies. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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