Commercial software upgrades may significantly alter Perfusion CT parameter values in colorectal cancer.
Objective: To determine how commercial software platform upgrades impact on derived parameters for colorectal cancer.Materials and Methods: Following ethical approval, 30 patients with suspected colorectal cancer underwent Perfusion CT using integrated 64 detector PET/CT before surgery. Analysis was...
| Publicado en: | European Radiology Vol. 21; no. 4; pp. 744 - 750 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104835388&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104835388 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2011 vid: 21 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104835388 58721749 NLM20922392 2010967838 10.1007/s00330-010-1967-4 NLM20922392 104835388 ppf: 744 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Commercial software upgrades may significantly alter Perfusion CT parameter values in colorectal cancer. aug: au: Goh V Shastry M Engledow A Reston J Wellsted DM Peck J Endozo R Rodriguez-Justo M Taylor SA Halligan S Groves AM Goh, Vicky Shastry, Manu Engledow, Alec Reston, Jonathan Wellsted, David M Peck, Jacqui Endozo, Raymondo Rodriguez-Justo, Manuel Taylor, Stuart A affil: Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK sug: subj: Adenocarcinoma Radiography Colonic Neoplasms Radiography Colorectal Neoplasms Radiography Radiographic Image Interpretation, Computer-Assisted Equipment and Supplies Rectal Neoplasms Radiography Tomography, X-Ray Computed Methods Adenocarcinoma Surgery Aged Aged, 80 and Over Colonic Neoplasms Surgery Colorectal Neoplasms Surgery Contrast Media Pharmacodynamics Female Human Male Middle Age Perfusion Radiographic Image Interpretation, Computer-Assisted Methods Rectal Neoplasms Surgery Software Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objective: To determine how commercial software platform upgrades impact on derived parameters for colorectal cancer.Materials and Methods: Following ethical approval, 30 patients with suspected colorectal cancer underwent Perfusion CT using integrated 64 detector PET/CT before surgery. Analysis was performed using software based on modified distributed parameter analysis (Perfusion software version 4; Perfusion 4.0), then repeated using the previous version (Perfusion software version 3; Perfusion 3.0). Tumour blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) were determined for identical regions-of-interest. Slice-by-slice and 'whole tumour' variance was assessed by Bland-Altman analysis.Results: Mean BF, BV and PS was 20.4%, 59.5%, and 106% higher, and MTT 14.3% shorter for Perfusion 4.0 than Perfusion 3.0. The mean difference (95% limits of agreement) were +13.5 (-44.9 to 72.0), +2.61 (-0.06 to 5.28), -1.23 (-6.83 to 4.36), and +14.2 (-4.43 to 32.8) for BF, BV, MTT and PS respectively. Within subject coefficient of variation was 36.6%, 38.0%, 27.4% and 60.6% for BF, BV, MTT and PS respectively indicating moderate to poor agreement.Conclusion: Software version upgrades of the same software platform may result in significantly different parameter values, requiring adjustments for cross-version comparison. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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