Risk factors associated with Helicobacter pylori infection treatment failure in a high prevalence area.
SUMMARYTriple therapy is commonly used for the treatment of Helicobacter pylori infection. We determined risk factors associated with its failure in compliant patients focusing on H. pylori density, virulence marker and 23S ribosomal RNA (rRNA) point mutations associated with clarithromycin resistan...
| Publicado en: | Epidemiology & Infection Vol. 139; no. 4; pp. 581 - 591 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Cambridge University Press
Apr2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104841224&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104841224 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09502688 2S0 jtl: Epidemiology & Infection issn: 09502688 maglogo: N pubinfo: dt: Apr2011 vid: 139 iid: 4 pid: 15979 pub: Cambridge University Press artinfo: ui: 104841224 2010973963 10.1017/S0950268810001226 NLM20525411 104841224 ppf: 581 ppct: 10 formats: tig: atl: Risk factors associated with Helicobacter pylori infection treatment failure in a high prevalence area. aug: au: Yakoob J Jafri W Abbas Z Abid S Naz S Khan R Khalid A affil: Department of Medicine, The Aga Khan University, Karachi, Pakistan. sug: subj: Antibiotics Administration and Dosage Helicobacter Infections Drug Therapy Helicobacter Infections Epidemiology Helicobacter Pylori Adolescence Adult Aged Aged, 80 and Over Amoxicillin Administration and Dosage Bacterial Proteins Breath Tests Clarithromycin Administration and Dosage Drug Resistance, Microbial Female Helicobacter Infections Diagnosis Male Middle Age Omeprazole Administration and Dosage Pakistan Mutation Prevalence RNA Risk Factors Treatment Failure Urea Analysis Toxins Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: SUMMARYTriple therapy is commonly used for the treatment of Helicobacter pylori infection. We determined risk factors associated with its failure in compliant patients focusing on H. pylori density, virulence marker and 23S ribosomal RNA (rRNA) point mutations associated with clarithromycin resistance. H. pylori infection was diagnosed by 14C urea breath test (14C UBT) and rapid urease test or histology. Triple therapy with esomeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d. and clarithromycin 500 mg b.i.d. was prescribed for 10 days. 14C UBT was repeated 4 weeks after treatment. In total, 111 patients [69 (62%) males] with a mean age of 46±16 years were enrolled. The mean age of treatment failure was 39±14 years compared to 48±16 years with eradication (P=0·002). Treatment failure was associated with younger mean age, point mutations in the 23S rRNA gene of H. pylori and vacA s1a and m1 when associated with cagA negativity. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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