Breast Hormonal Receptors Test Should Be Repeated on Excisional Biopsy After Negative Core Needle Biopsy.
Therapeutic decision-making for women diagnosed with breast cancer requires accurate determination of the estrogen receptor (ER) and progesterone receptor (PR). Decisions about adjuvant therapy are often based on the immunohistochemical (IHC) profile of the core needle biopsy sample (CNB) because th...
| Publicado en: | Breast Journal Vol. 17; no. 2; pp. 180 - 187 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar/Apr2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104844754&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104844754 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1075122X ET6 jtl: Breast Journal issn: 1075122X maglogo: Y pubinfo: dt: Mar/Apr2011 vid: 17 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104844754 59318805 10.1111/j.1524-4741.2010.01051.x NLM21306471 104844754 ppf: 180 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Breast Hormonal Receptors Test Should Be Repeated on Excisional Biopsy After Negative Core Needle Biopsy. aug: au: Khoury, Thaer Zakharia, Yousef Tan, Wei Kulkarni, Swati Liu, Weiguo Zhang, Shanxiang Wilding, Gregory E. Edge, Stephen affil: Department of Pathology, Roswell Park Cancer Institute sug: subj: Breast Neoplasms Diagnosis Biopsy Estrogens Analysis Human Biopsy, Needle Descriptive Statistics kappa Statistic Sensitivity and Specificity Spearman's Rank Correlation Coefficient Data Analysis, Statistical Data Analysis Software Neoplasm Staging Confidence Intervals ab: Therapeutic decision-making for women diagnosed with breast cancer requires accurate determination of the estrogen receptor (ER) and progesterone receptor (PR). Decisions about adjuvant therapy are often based on the immunohistochemical (IHC) profile of the core needle biopsy sample (CNB) because the staining is not repeated on the final excisional biopsy (EB). The purpose of this study was to assess the concordance of breast cancer IHC receptor assays on CNB and EB. We identified 176 patients with matching breast CNB and EB that had available ER and PR. While the CNBs were processed and stained in different laboratories, the EB were processed and stained in our institution. The following antibodies were used 1D5, 6F11 and SP1 for ER, and PgR636, 16 and 1E2 for PR, from Dako, Leica and Ventana respectively. Correlation of scores of CNBs with matching EB was analyzed using Spearman correlation coefficients. Sensitivity, specificity, overall agreement and the kappa statistic were used to measure the concordance between CNB and EB. For CNB, there were 141 (80.1%) cases positive for ER and 118 (67%) cases positive for PR. For EB, there were 143 (81.3%) cases positive for ER and 130 (73.9%) cases positive for PR. Overall agreement for ER and PR was seen in 93% (95% CI = 0.88, 0.96) and 90% (95% CI = 0.84, 0.94) respectively. Overall, ER− CNB/ER+ EB was seen in seven (4%) cases and PR− CNB/PR+ EB in 15 (8.5%) cases. ER+ CNB/ER− EB was seen in five (2.8%) cases and PR+ CNB/PR− EB in three (1.7%) cases. To avoid erroneous omission of life-saving endocrine therapy ER and PR should be repeated on the EB for patients whose CNB has negative hormonal receptors. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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