Early Left Ventricular Longitudinal Systolic Dysfunction and Cardiovascular Risk Factors in 1,371 Asymptomatic Subjects with Normal Ejection Fraction: A Tissue Doppler Study.
Background: Nowadays early diagnosis of left ventricular (LV) dysfunction represents a major challenge in asymptomatic subjects with cardiovascular (CV) risk factors. Tissue Doppler imaging (TDI) recently emerged as an important tool with clinical relevance in several cardiac diseases. Aim: To evalu...
| Publicado en: | Echocardiography Vol. 28; no. 3; pp. 268 - 276 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104844838&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104844838 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Mar2011 vid: 28 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104844838 59318601 10.1111/j.1540-8175.2010.01327.x NLM21395669 104844838 ppf: 268 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Early Left Ventricular Longitudinal Systolic Dysfunction and Cardiovascular Risk Factors in 1,371 Asymptomatic Subjects with Normal Ejection Fraction: A Tissue Doppler Study. aug: au: Di Salvo, Giovanni Di Bello, Vitantonio Salustri, Alessandro Antonini-Canterin, Francesco La Carrubba, Salvatore Materazzo, Carlo Badano, Luigi Caso, Pio Pezzano, Antonio Calabrò, Raffaele Carerj, Scipione affil: Second University of Naples, Naples, Italy sug: subj: Systole Cardiovascular Risk Factors Echocardiography, Doppler Heart Ventricle, Left Physiology Human Male Female Descriptive Statistics P-Value Middle Age Multivariate Analysis Diastole Italy One-Way Analysis of Variance Logistic Regression Adult Heart Ventricle, Left Pathology Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Background: Nowadays early diagnosis of left ventricular (LV) dysfunction represents a major challenge in asymptomatic subjects with cardiovascular (CV) risk factors. Tissue Doppler imaging (TDI) recently emerged as an important tool with clinical relevance in several cardiac diseases. Aim: To evaluate the ability of TDI in detecting early longitudinal ventricular dysfunction in asymptomatic subjects, with LV ejection fraction >55%, normal diastolic function, and its relationship with CV risk factors. Methods: A total of 1,371 subjects (median age 60 years, 595 males) formed our study population: Controls, 265 healthy subjects; Group I, 434 subjects with one CV risk factor; Group II, 401 subjects with two CV risk factors; Group III, 271 subjects with ≥ 3 CV risk factors. All subjects underwent a comprehensive standard echo Doppler evaluation, including PW-TDI study. Results: Diastolic parameters such as (E\A, A-wave, Em\Am; E\Em) were able to discriminate the number of CV risk factors. The only systolic parameter that progressively reduced by increasing the number of CV risk factors was LV global longitudinal systolic function (Sm), (P < 0.0001). At multivariate analysis, the only functional parameter able to predict the increasing number of CV risk factors was Sm (P < 0.001). Conclusions: TDI is able to identify early longitudinal LV systolic abnormalities in presence of apparently normal systolic and diastolic function and progressively impairs with increasing CV risk factors. These findings could be clinically relevant in identifying asymptomatic subjects who need a early tailored preventive treatment. (Echocardiography 2011;28:268-275) pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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