Explicit and implicit memory in late-life depression.
Objective: Late-life depression has been associated with memory loss and is frequently assumed to be a risk factor for continued cognitive decline. This study examined cognition in patients with late-life depression with a focus on the assessment of the extent and type of memory loss among elderly d...
| Publicado en: | American Journal of Geriatric Psychiatry Vol. 19; no. 4; pp. 249 - 256 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Apr2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104852843&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104852843 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10647481 GIF jtl: American Journal of Geriatric Psychiatry issn: 10647481 maglogo: N pubinfo: dt: Apr2011 vid: 19 iid: 4 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 104852843 NLM20808121 2010988367 10.1097/JGP.0b013e3181e89a5b NLM20808121 104852843 ppf: 249 ppct: 7 formats: tig: atl: Explicit and implicit memory in late-life depression. aug: au: Elderkin-Thompson V Moody T Knowlton B Hellemann G Kumar A Elderkin-Thompson, Virginia Moody, Teena Knowlton, Barbara Hellemann, Gerhard Kumar, Anand affil: Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90024–1759, USA sug: subj: Cognition Disorders Psychosocial Factors Depression Psychosocial Factors Memory Disorders Psychosocial Factors Aged Attention Cognition Disorders Complications Cross Sectional Studies Depression Complications Female Geriatric Assessment Methods Hamilton Rating Scale for Depression Human Language Tests Male Memory Memory Disorders Complications Mental Processes Neuropsychological Tests Psychological Tests Scales Urban Population Aged: 65+ years Female Male ab: Objective: Late-life depression has been associated with memory loss and is frequently assumed to be a risk factor for continued cognitive decline. This study examined cognition in patients with late-life depression with a focus on the assessment of the extent and type of memory loss among elderly depressed patients.Methods: Two-year cross-sectional study of elderly depressed (N = 112) and nondepressed (N = 138) individuals at or older than 60 years in an urban area surrounding a major medical center in southern California. Participants had little to moderate stroke risk. Volunteers were screened with the Hamilton Depression Rating Scale and the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) Axis I Disorders. Patients were diagnosed for major depression by a geriatric psychiatrist using DSM-IV criteria. Volunteers completed neuropsychological testing, a standard battery of laboratory tests, and a neurologic and psychiatric evaluation to rule out a medical burden that might contribute to depression or early dementia.Results: Depressed patients showed deficits in attention and processing, executive function, and immediate explicit recall. Implicit learning and episodic recall of the testing procedure, semantic and phonetic fluency, and retention of newly acquired verbal material after a delay period were comparable with controls.Conclusion: Moderately depressed patients demonstrate a pattern of cognitive deficits suggestive of mild frontal dysfunction during recall tasks. Their retention of material over a delay period and their intact language skills indicate medial hippocampal function similar to controls. Subcortically mediated implicit memory is also at normal levels. These findings support current efforts to identify pathways of frontal and/or striatal compromise during depressive episodes. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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