Outcome and reproducibility of data concerning the Oxford unicompartmental knee arthroplasty.
Background and purpose The reproducibility of results and potential confounders in sample-based studies is important to consider in the assessment of studies. Comprehensive arthroplasty registers could serve as a reference dataset for comparative analyses. We analyzed an implant that is frequently u...
| Published in: | Acta Orthopaedica Vol. 82; no. 2; pp. 131 - 136 |
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| Main Authors: | , , , , |
| Format: | research systematic review Journal Article |
| Published: |
Medical Journals Sweden AB
Apr2011
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104862814&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104862814 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17453674 1BVL jtl: Acta Orthopaedica issn: 17453674 maglogo: N pubinfo: dt: Apr2011 vid: 82 iid: 2 pid: 59195 pub: Medical Journals Sweden AB artinfo: ui: 104862814 59761492 10.3109/17453674.2011.566134 NLM21434760 104862814 ppf: 131 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Outcome and reproducibility of data concerning the Oxford unicompartmental knee arthroplasty. aug: au: Labek, Gerold Sekyra, Kathrin Pawelka, Wolfram Janda, Wolfgang Stööckl, Bernd affil: Department of Orthopaedics, Innsbruck Medical University, Innsbruck, Austria sug: subj: Reproducibility of Results Evaluation Arthroplasty, Replacement, Knee Orthopedic Prosthesis Reoperation Treatment Outcomes Systematic Review Meta Analysis Bias (Research) PubMed Medline Confidence Intervals Prospective Studies Data Analysis Software Funding Source ab: Background and purpose The reproducibility of results and potential confounders in sample-based studies is important to consider in the assessment of studies. Comprehensive arthroplasty registers could serve as a reference dataset for comparative analyses. We analyzed an implant that is frequently used worldwide, the Oxford unicompartmental knee replacement, in order to identify potential confounders inherent in the datasets and to evaluate the outcome achieved with this implant. Methods We performed a structured literature review of the data published on the revision rate of the Oxford medial unicompartmental arthroplasty. Both clinical follow-up studies and worldwide registry data were included. Confidence intervals were calculated to determine the statistical significance of differences. Results A substantial proportion of the published data (52--68% depending on the method of calculation) is derived from studies involving participation of the institution that developed the implant. The results published by this group show a statistically significant deviation from the reference datasets from registers or independent studies. Data from the developing hospital show mean revision rates that are 4 times lower than those based on worldwide register data, and 3 times lower than the ones quoted in independent studies. On average, the data published in independent studies are reproducible in registry data. Interpretation A conventional meta-analysis of clinical studies is substantially affected by the influence of the developing hospital, and is therefore subject to bias. For assessment of the outcome of implants, registry data are superior and, in terms of reference data for the detection of potential bias factors in the literature, could make an essential contribution to meta-analyses. pubtype: Academic Journal doctype: meta analysis research systematic review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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