Signal intensity in T2' magnetic resonance imaging is related to brain glioma grade.
Objectives: T2' values reflect the presence of deoxyhaemoglobin related to high local oxygen extraction. We assessed the feasibility of T2' imaging to display regions with high metabolic activity in brain gliomas.Methods: MRI was performed in 25 patients (12 female; median age 46 years; range 2-69)...
| Publicado en: | European Radiology Vol. 21; no. 5; pp. 1068 - 1077 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
May2011
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104866644&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104866644 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2011 vid: 21 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104866644 59834536 NLM21069342 2011005011 10.1007/s00330-010-2004-3 NLM21069342 104866644 ppf: 1068 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Signal intensity in T2' magnetic resonance imaging is related to brain glioma grade. aug: au: Saitta L Heese O Förster AF Matschke J Siemonsen S Castellan L Westphal M Fiehler J Goebell E Saitta, Laura Heese, Oliver Förster, Ann-Freya Matschke, Jakob Siemonsen, Susanne Castellan, Lucio Westphal, Manfred Fiehler, Jens Goebell, Einar affil: Department of Diagnostic and Interventional Neuroradiology, San Martino Hospital, Pad Specialità, Largo Benzi 10, 16132 Genoa, Italy sug: subj: Brain Neoplasms Diagnosis Brain Neoplasms Pathology Glioma Diagnosis Glioma Pathology Magnetic Resonance Imaging Methods Adolescence Adult Aged Child Child, Preschool Female Hemoglobins Metabolism Male Middle Age Oxygen Retrospective Design Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Child: 6-12 years Child, Preschool: 2-5 years Middle Aged: 45-64 years Female Male ab: Objectives: T2' values reflect the presence of deoxyhaemoglobin related to high local oxygen extraction. We assessed the feasibility of T2' imaging to display regions with high metabolic activity in brain gliomas.Methods: MRI was performed in 25 patients (12 female; median age 46 years; range 2-69) with brain gliomas with additional T2 and T2* sequences. T2' maps were derived from T2 and T2*. Dynamic susceptibility weighted contrast (DSC) perfusion was performed in 12/25 patients. Images were visually assessed by two readers and five ROIs were evaluated for each patient. Pearson correlation, Mann-Whitney and Kruskal-Wallis tests were applied for statistical analysis.Results: Three patients were not further evaluated because of artefacts. Mean values of high-grade (III-IV) gliomas showed significantly lower T2' values than low-grade (II) gliomas (p < 0.001). An inverse relationship was observed between rCBV and sqr (T2') (r = -0.463, p < 0.001). No correlation was observed between T2' and rCBV for grade II tumours (r = 0.038; p = 0.875).Conclusions: High-grade tumours revealed lower T2' values, presumably because of higher oxygen consumption in proliferating tissue. Our results indicate that T2' imaging can be used as an alternative to DSC perfusion in the detection of subtle deviations in tumour metabolism. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|