Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma.
Objectives: The exact cause of benign prostatic hyperplasia (BPH) and prostatic carcinoma is unknown. Changes in the level of the trace element zinc (Zn) are known to be associated with the functioning of different organs (breast, colon, stomach, liver, kidney, prostate, and muscle). This study is a...
| Published in: | Indian Journal of Urology Vol. 27; no. 1; pp. 14 - 19 |
|---|---|
| Main Authors: | , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wolters Kluwer India Pvt Ltd
Jan-Mar2011
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104869096&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104869096 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09701591 1KUG jtl: Indian Journal of Urology issn: 09701591 maglogo: N pubinfo: dt: Jan-Mar2011 vid: 27 iid: 1 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 104869096 59924299 10.4103/0970-1591.78405 104869096 ppf: 14 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma. aug: au: Christudoss, Pamela Selvakumar, R. Fleming, Joseph J. Gopalakrishnan, Ganesh affil: Department of Clinical Biochemistry, Christian Medical College, Vellore, India sug: subj: Zinc Analysis Prostatic Hypertrophy Physiopathology Prostatic Neoplasms Physiopathology Human Zinc Urine Zinc Blood Prostatic Hypertrophy Risk Factors Prostatic Neoplasms Risk Factors Prostatic Neoplasms Metabolism Prostatic Hypertrophy Metabolism Male India Hospital Units Middle Age Aged Aged, 80 and Over Descriptive Statistics Paired T-Tests Analysis of Variance Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male ab: Objectives: The exact cause of benign prostatic hyperplasia (BPH) and prostatic carcinoma is unknown. Changes in the level of the trace element zinc (Zn) are known to be associated with the functioning of different organs (breast, colon, stomach, liver, kidney, prostate, and muscle). This study is aimed at estimating and comparing the zinc levels in the prostate tissue, plasma, and urine obtained from patients diagnosed with BPH or prostatic carcinoma. Materials and Methods: The prostate tissue zinc, plasma zinc, and urine zinc/creatinine ratio in BPH, prostate cancer, and normal subjects were measured by atomic absorption spectrophotometry. Results: In prostate carcinoma, the mean tissue zinc was decreased by 83% as compared to normal tissue and in BPH, there was a 61% decrease in mean tissue zinc as compared to normal tissues. Both these values were statistically significant. The plasma zinc in prostate cancer patients showed a 27% decrease (P < 0.01) as compared to controls and 18% decrease (P < 0.01) as compared to BPH. The urine zinc/creatinine (ratio) was significantly increased to 53% in prostate cancer patients, and a 20% significant increase was observed in BPH as compared to normal subjects. Conclusions: It is evident from this study that BPH or prostate carcinoma may be associated with a reduction in the levels of tissue zinc, plasma zinc, and an increase in urine zinc/creatinine. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|