Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma.

Rationale: Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are fully humanized IgG(1) antibodies that bind to different epitopes and neutralize IL-13 bioactivity. Objectives: We hypothesized that anti-IL-13 treatment would inhibit alle...

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Publicado en:	American Journal of Respiratory & Critical Care Medicine Vol. 183; no. 8; pp. 1007 - 1015
Autores principales:	Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM
Formato:	research randomized controlled trial Journal Article
Publicado:	Oxford University Press / USA 4/15/2011
Acceso en línea:	Ver este registro en EBSCOhost