Factors associated with non-adherence to antiretroviral therapy in the SUN study.
Background. Adherence of 95% or greater to highly active combination antiretroviral therapy is generally considered necessary to achieve optimal virologic suppression in HIV-infected patients. Understanding factors associated with poor adherence is essential to improve patient compliance, maximize v...
| Publicado en: | AIDS Care Vol. 23; no. 5; pp. 601 - 612 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
May2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104875401&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104875401 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09540121 AAE jtl: AIDS Care issn: 09540121 maglogo: N pubinfo: dt: May2011 vid: 23 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104875401 60040873 10.1080/09540121.2010.525603 NLM21293992 104875401 ppf: 601 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Factors associated with non-adherence to antiretroviral therapy in the SUN study. aug: au: Kyser, Melanie Buchacz, Kate Bush, Timothy J. Conley, Lois J. Hammer, John Henry, Keith Kojic, Erna M. Milam, Joel Overton, E. Turner Wood, Kathy C. Brooks, John T. affil: National Center for HIV/AIDS, Viral Hepatitis, TB, and STD Prevention, Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention, Atlanta, GA, USA sug: subj: Antiviral Agents Medication Compliance Human Descriptive Statistics Multiple Logistic Regression Odds Ratio Confidence Intervals Evaluation Research Questionnaires Prospective Studies Male Female Young Adult Adult Middle Age Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background. Adherence of 95% or greater to highly active combination antiretroviral therapy is generally considered necessary to achieve optimal virologic suppression in HIV-infected patients. Understanding factors associated with poor adherence is essential to improve patient compliance, maximize virologic suppression, and reduce morbidity and mortality. Methods. We evaluated baseline data from 528 patients taking antiretrovirals, enrolled from March 2004 to June 2006, in a multicenter, longitudinal, prospective cohort study (the SUN study). Using multiple logistic regression, we examined independent risk factors for non-adherence, defined as reporting having missed one or more antiretroviral doses in the past three days on the baseline questionnaire. Results. Of 528 participants (22% female, 28% black, median age 41 years, and median CD4 cell count 486 cells/mm3), 85 (16%) were non-adherent. In the final parsimonious multivariate model, factors independently associated with non-adherence included black race (adjusted odds ratio (aOR): 2.08, 95% confidence interval (CI): 1.20-3.60 vs. white race), being unemployed and looking for work (aOR: 2.03, 95% CI: 1.14-3.61 vs. all other employment categories), having been diagnosed with HIV ≥5 years ago (aOR: 1.95, 95% CI: 1.18-3.24 vs. being HIV-diagnosed <5 years ago), drinking three or more drinks per day (aOR: 1.73, 95% CI: 1.02-2.91 vs. drinking <3 drinks per day), and having not engaged in any aerobic exercise in the last 30 days (aOR: 2.13, 95% CI: 1.25-3.57). Conclusion. Although the above factors may not be causally related to non-adherence, they might serve as proxies for identifying HIV-infected patients at greatest risk for non-adherence who may benefit from additional adherence support. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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