Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy.
Objective:We undertook this study to assess the agreement between fetal umbilical cord drug levels and maternal self-report.Study Design:Cord samples were collected from 103 placentas after delivery as a subproject of the larger Pacific Research Center for Early Human Development (PRCEHD) study. The...
| Publicado en: | Journal of Perinatology Vol. 31; no. 5; pp. 324 - 330 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas research Journal Article |
| Publicado: |
Springer Nature
May2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104882196&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104882196 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07438346 DZF jtl: Journal of Perinatology issn: 07438346 maglogo: Y pubinfo: dt: May2011 vid: 31 iid: 5 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 104882196 60243750 10.1038/jp.2010.132 NLM21151006 104882196 ppf: 324 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy. aug: au: Wright, T E Milam, K A Rougee, L Tanaka, M D Collier, A C affil: Department of Obstetrics, Gynecology and Women's Health, University of Hawaii John A Burns School of Medicine, Honolulu, HI, USA sug: subj: Substance Abuse Diagnosis Smoking Diagnosis Cotinine Blood Street Drugs Analysis Fetal Blood Human Pregnancy Self Report Enzyme-Linked Immunosorbent Assay kappa Statistic Sensitivity and Specificity Prospective Studies Hawaii Amphetamines Analysis Cannabis Analysis Cocaine Analysis Narcotics Analysis Descriptive Statistics Data Analysis Software Goodness of Fit Chi Square Test Confidence Intervals Predictive Value of Tests Female Adult Funding Source Adult: 19-44 years Female ab: Objective:We undertook this study to assess the agreement between fetal umbilical cord drug levels and maternal self-report.Study Design:Cord samples were collected from 103 placentas after delivery as a subproject of the larger Pacific Research Center for Early Human Development (PRCEHD) study. These cord samples were then processed to obtain cord lysates and enzyme-linked immunosorbent assay (ELISA) performed for cotinine and illicit drugs. Levels of each of these substances were compared with clinical information.Result:We found fair agreement between self-reported smoking and cotinine levels (κ=0.26 (0.07 to 0.5)) as well as slight agreement with current drug use and positive drug levels (κ=0.19 (−0.05 to 0.4)). Compared with maternal self-report, sensitivity of cotinine levels was 27% and specificity was 98%. Sensitivity of positive cord illicit drug levels was 32% and specificity was 85%.Conclusion:Umbilical cords provide another independent measure of maternal drug use and are readily available. To our knowledge, this is the first study to measure cotinine levels in the umbilical cord tissue. pubtype: Academic Journal doctype: equations & formulas research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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