The correlation of serum transaminase values with fibrosis staging and necroinflammatory activity scores in chronic hepatitis.
Objective: The aim of this study is to compare the necroinflammatory activity score / histological activity index (HAI) and fibrosis score detected in liver biopsies with serum transaminase levels of chronic hepatitis B, C and steatohepatitis. Material and Methods: This retrospective study included...
| Published in: | Turkiye Klinikleri Journal of Medical Sciences Vol. 31; no. 1; pp. 68 - 75 |
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| Main Authors: | , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Turkiye Klinikleri
Feb2011
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104888954&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104888954 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Feb2011 vid: 31 iid: 1 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104888954 2011035952 10.5336/medsci.2009-16514 104888954 ppf: 68 ppct: 7 formats: fmt: @attributes: type: P tig: atl: The correlation of serum transaminase values with fibrosis staging and necroinflammatory activity scores in chronic hepatitis. aug: au: Ozkara, Selvinaz Tosun, Ilkay Sari, Bilgen Kilic, Guray Aker, Fugen Vardar Sezikli, Mesut Guzelbulut, Fatih Bor, Emire affil: Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey sug: subj: Alanine Aminotransferase Blood Chronic Disease Fibrosis Hepatitis Physiopathology Adult Aspartate Aminotransferase Blood Biopsy Descriptive Statistics Female Human Male Mann-Whitney U Test Middle Age Retrospective Design Spearman's Rank Correlation Coefficient Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: The aim of this study is to compare the necroinflammatory activity score / histological activity index (HAI) and fibrosis score detected in liver biopsies with serum transaminase levels of chronic hepatitis B, C and steatohepatitis. Material and Methods: This retrospective study included total of 398 cases whose liver biopsies were performed because increased liver enzyme levels and had the diagnoses of chronic hepatitis B, hepatitis C or steatohepatitis ofter liver biopsy between 2003-2007. The HAI and fibrosis scores of all cases were evaluated according to ISHAK classification criteria and then the results were compared with the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels at the time of biopsy. Results: When all cases were considered, serum AST values emerged as the most statistically significant variable for hepatic fibrosis (r:0.311; p<0.01). Additionally, there was a correlation between AST values and HAI (r:0.295; p<0.01). On the other hand, serum ALT values did not correlate with (r:0.094; p>0.05) the extent of hepatic fibrosis but correlated weakly with HAI (r:0.242; p<0.01). Conclusion: Serum AST level is found to be a significant indicator of histological activity index and fibrosis as well as hepatic damage. These findings suggested that, among other factors, serum AST values should be considered in decisions regarding the need for liver biopsy and treatment in patients with chronic hepatitis. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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