Magnetic resonance imaging findings in acute myocarditis and correlation with immunohistological parameters.
Objective: To evaluate the role of MRI in diagnosing acute myocarditis by correlation with immunohistological parameters.Methods: A total of 131 patients (85 men, 46 women; mean age, 44.9 years) with suspected acute myocarditis were examined by MRI. The relative water content of the left ventricular...
| Publicado en: | European Radiology Vol. 21; no. 6; pp. 1259 - 1267 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104891238&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104891238 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2011 vid: 21 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104891238 60411146 NLM21116631 2011040849 10.1007/s00330-010-2022-1 NLM21116631 PMC3088804 104891238 ppf: 1259 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Magnetic resonance imaging findings in acute myocarditis and correlation with immunohistological parameters. aug: au: Röttgen R Christiani R Freyhardt P Gutberlet M Schultheiss HP Hamm B Kühl U Röttgen, Rainer Christiani, Robert Freyhardt, Patrick Gutberlet, Matthias Schultheiss, Hans Peter Hamm, Bernd Kühl, Uwe affil: Klinik für Strahlenheilkunde, Campus Virchow-Klinikum, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany sug: subj: Magnetic Resonance Imaging Methods Myocardial Diseases Pathology Acute Disease Adult Female Male Middle Age Reproducibility of Results Sensitivity and Specificity Statistics Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: To evaluate the role of MRI in diagnosing acute myocarditis by correlation with immunohistological parameters.Methods: A total of 131 patients (85 men, 46 women; mean age, 44.9 years) with suspected acute myocarditis were examined by MRI. The relative water content of the left ventricular myocardium as well as relative and late enhancement was correlated with the immunohistological results in biopsy specimens.Results: Myocardial inflammation was confirmed by immunohistology in 82 of the 131 patients investigated and ruled out in 49 patients. The sensitivity, specificity and accuracy for diagnosing myocarditis in patients with immunohistologically proven disease were 48.8%, 73.8% and 57.3%, respectively, for relative enhancement, 58.3%, 57.1% and 57.9% for relative water content, and 30.6%, 88.1% and 49.6% for late enhancement. A combination of all three parameters had 39,3% sensitivity and 91,3% specificity and 62,7% accuracy. Relative enhancement and late enhancement significantly correlated with the presence of myocarditis but relative oedema did not.Conclusion: Relative and late enhancement significantly correlate with the presence of myocarditis, while there is no significant correlation for relative oedema. Myocarditis cannot be reliably diagnosed using any of the three MRI parameters alone but combinations of parameters will improve specificity. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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