Computer-aided detection of pulmonary embolism at CT pulmonary angiography: can it improve performance of inexperienced readers?

Purpose: To evaluate the effect of a computer-aided detection (CAD) algorithm on the performance of novice readers for detection of pulmonary embolism (PE) at CT pulmonary angiography (CTPA).Materials and Methods: We included CTPA examinations of 79 patients (50 female, 52 ± 18 years). Studies were...

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Published in:European Radiology Vol. 21; no. 6; pp. 1214 - 1224
Main Authors: Blackmon KN, Florin C, Bogoni L, McCain JW, Koonce JD, Lee H, Bastarrika G, Thilo C, Costello P, Salganicoff M, Joseph Schoepf U, Blackmon, Kevin N, Florin, Charles, Bogoni, Luca, McCain, Joshua W, Koonce, James D, Lee, Heon, Bastarrika, Gorka, Thilo, Christian, Costello, Philip
Format: research Journal Article
Published: Springer Nature Jun2011
Online Access:View this record in EBSCOhost
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      dt: Jun2011
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      pub: Springer Nature
      place: New York, New York
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        atl: Computer-aided detection of pulmonary embolism at CT pulmonary angiography: can it improve performance of inexperienced readers?
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          Blackmon KN
          Florin C
          Bogoni L
          McCain JW
          Koonce JD
          Lee H
          Bastarrika G
          Thilo C
          Costello P
          Salganicoff M
          Joseph Schoepf U
          Blackmon, Kevin N
          Florin, Charles
          Bogoni, Luca
          McCain, Joshua W
          Koonce, James D
          Lee, Heon
          Bastarrika, Gorka
          Thilo, Christian
          Costello, Philip
        affil: Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226 25 Courtenay Drive, Charleston, SC 29401, USA
      sug:
        subj:
          Algorithms
          Angiography Methods
          Professional Competence
          Pulmonary Artery Radiography
          Pulmonary Embolism Radiography
          Radiographic Image Interpretation, Computer-Assisted Methods
          Tomography, X-Ray Computed Methods
          Artificial Intelligence
          Female
          Male
          Middle Age
          Observer Bias
          Reproducibility of Results
          Sensitivity and Specificity
          South Carolina
          Middle Aged: 45-64 years
          Female
          Male
      ab: Purpose: To evaluate the effect of a computer-aided detection (CAD) algorithm on the performance of novice readers for detection of pulmonary embolism (PE) at CT pulmonary angiography (CTPA).Materials and Methods: We included CTPA examinations of 79 patients (50 female, 52 ± 18 years). Studies were evaluated by two independent inexperienced readers who marked all vessels containing PE. After 3 months all studies were reevaluated by the same two readers, this time aided by CAD prototype. A consensus read by three expert radiologists served as the reference standard. Statistical analysis used χ(2) and McNemar testing.Results: Expert consensus revealed 119 PEs in 32 studies. For PE detection, the sensitivity of CAD alone was 78%. Inexperienced readers' initial interpretations had an average per-PE sensitivity of 50%, which improved to 71% (p < 0.001) with CAD as a second reader. False positives increased from 0.18 to 0.25 per study (p = 0.03). Per-study, the readers initially detected 27/32 positive studies (84%); with CAD this number increased to 29.5 studies (92%; p = 0.125).Conclusion: Our results suggest that CAD significantly improves the sensitivity of PE detection for inexperienced readers with a small but appreciable increase in the rate of false positives.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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