Protocol modifications for CT perfusion (CTp) examinations of abdomen-pelvic tumors: impact on radiation dose and data processing time.
Purpose: To evaluate the effect of CT perfusion (CTp) protocol modifications on quantitative perfusion parameters, radiation dose and data processing time.Materials& Methods: CTp datasets of 30 patients (21M:9F) with rectal (n = 24) or retroperitoneal (n = 6) tumours were studied. Standard CTp proto...
| Publicado en: | European Radiology Vol. 21; no. 6; pp. 1293 - 1301 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104891258&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104891258 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2011 vid: 21 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104891258 60411126 NLM21246200 2011040869 10.1007/s00330-010-2048-4 NLM21246200 104891258 ppf: 1293 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Protocol modifications for CT perfusion (CTp) examinations of abdomen-pelvic tumors: impact on radiation dose and data processing time. aug: au: Kambadakone AR Sharma A Catalano OA Hahn PF Sahani DV Kambadakone, Avinash R Sharma, Ashish Catalano, Onofrio A Hahn, Peter F Sahani, Dushyant V affil: Department of Radiology, Division of Abdominal Imaging and Interventional Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA sug: subj: Abdominal Neoplasms Radiography Pelvic Neoplasms Radiography Perfusion Imaging Methods Radiologic Health Methods Radiography, Abdominal Methods Tomography, X-Ray Computed Methods Adult Aged Female Male Middle Age Radiometry Reproducibility of Results Sensitivity and Specificity Workload Young Adult Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Purpose: To evaluate the effect of CT perfusion (CTp) protocol modifications on quantitative perfusion parameters, radiation dose and data processing time.Materials& Methods: CTp datasets of 30 patients (21M:9F) with rectal (n = 24) or retroperitoneal (n = 6) tumours were studied. Standard CTp protocol included 50 sec cine-phase (0.5 sec/rotation) and delayed-phase after 70 ml contrast bolus at 5-7 ml/sec. CTp-data was sub-sampled to generate modified datasets (n = 105) with cine-phase(n = 15) alone, varying cine-phase duration (20-40 sec, n = 45) and varying temporal sampling-interval (1-3 sec, n = 45). The estimated CTp parameters (BF,BV,MTT&PS) and radiation dose of standard CTp served as reference for comparison.Results: CTp with 50 sec cine-phase showed moderate to high correlation with standard CTp for BF&MTT (r = 0.96&0.85) and low correlation for BV (0.75, p = 0.04). Limiting cine-phase duration to 30 sec demonstrated comparable results for BF&MTT, while considerable variation in CTp values existed at 20 sec. There was moderate-to-high correlation of CTp parameters with sampling interval of 1&2 sec (r = 0.83-0.97, p > 0.05), while at 3 sec only BF showed high correlation (r = 0.96, p = 0.05). Increasing sampling interval (47-60%) and reducing cine-phase duration substantially reduced dose(30.8-65%) which paralleled reduced data processing time (3-10 min).Conclusion: Limiting CTp cine-phase to 30 sec results in comparable BF&MTT values and increasing cine-phase sampling interval to 2 sec provides good correlation for all CTp parameters with substantial dose reduction and improved computational efficiency. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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