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Predictors of Invasion and Axillary Lymph Node Metastasis in Patients with a Core Biopsy Diagnosis of Ductal Carcinoma In Situ: An Analysis of 255 Cases.

The diagnosis of ductal carcinoma in situ (DCIS) using core biopsy does not ensure the absence of invasion on final excision. We performed a retrospective analysis of 255 patients with DCIS who had subsequent excision. Clinical, radiologic, and pathologic findings were correlated with risk of invasi...

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Published in:Breast Journal Vol. 17; no. 3; pp. 223 - 230
Main Authors: Han, Jeong S., Molberg, Kyle H., Sarode, Venetia
Format: research tables/charts Journal Article
Published: Wiley-Blackwell May/Jun2011
Online Access:View this record in EBSCOhost
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      dt: May/Jun2011
      vid: 17
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        104895938
        60419448
        10.1111/j.1524-4741.2011.01069.x
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        104895938
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      tig:
        atl: Predictors of Invasion and Axillary Lymph Node Metastasis in Patients with a Core Biopsy Diagnosis of Ductal Carcinoma In Situ: An Analysis of 255 Cases.
      aug:
        au:
          Han, Jeong S.
          Molberg, Kyle H.
          Sarode, Venetia
        affil: Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas
      sug:
        subj:
          Carcinoma, Ductal, Breast Diagnosis
          Neoplasm Metastasis Diagnosis
          Neoplasm Metastasis Risk Factors
          Sentinel Lymph Node Biopsy Evaluation
          Human
          Female
          Mammography
          Retrospective Design
          Descriptive Statistics
          Record Review
          Adult
          Middle Age
          Aged
          Aged, 80 and Over
          P-Value
          One-Way Analysis of Variance
          Post Hoc Analysis
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Female
      ab: The diagnosis of ductal carcinoma in situ (DCIS) using core biopsy does not ensure the absence of invasion on final excision. We performed a retrospective analysis of 255 patients with DCIS who had subsequent excision. Clinical, radiologic, and pathologic findings were correlated with risk of invasion and sentinel lymph node (SLN) metastasis. Of 255 patients with DCIS, 199 had definitive surgery and 52 (26%) had invasive ductal carcinoma (IDC) on final excision. Extent of abnormal microcalcification on mammography, and presence of a radiologic/palpable mass and solid type of DCIS were significantly associated with invasion on final excision. Sentinel lymph node biopsy was performed in 131 (65.8%) patients of whom 18 (13.4%) had metastasis. Size of IDC and extent of DCIS on final pathology were significantly associated with positive SLN. Micrometastasis and isolated tumor cells comprised majority (71.4%) of the metastases in DCIS. SLN biopsy should be considered in those with high risk DCIS.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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