HbA1c does not always estimate average glucose.
Hemoglobin Alc (HbAlc) testing can be inaccurate in persons with elevated amounts of Hemoglobin F, or with abnormal hemoglobins found in sickle cell trait, HbC trait and HbE trait. These variants are more prevalent in African and Asian Americans, the same demographic that has an increased risk of di...
| Publicado en: | Clinical Laboratory Science Vol. 24; no. 2; pp. 71 - 78 |
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| Autores principales: | , |
| Formato: | case study tables/charts Journal Article |
| Publicado: |
American Society for Clinical Laboratory Science
Spring2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104903435&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104903435 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0894959X IKL jtl: Clinical Laboratory Science issn: 0894959X maglogo: N pubinfo: dt: Spring2011 vid: 24 iid: 2 pid: 13703 pub: American Society for Clinical Laboratory Science place: Dundee, Michigan artinfo: ui: 104903435 2011061780 10.29074/ascls.24.2.71 NLM21657138 104903435 ppf: 71 ppct: 7 formats: fmt: @attributes: type: P tig: atl: HbA1c does not always estimate average glucose. aug: au: Behan, Kristina J. Merschen, Jane affil: University of West Florida, Pensacola, FL sug: subj: Blood Glucose Analysis Diagnostic Errors Glycated Hemoglobin Hemoglobinopathies Laboratory Test Interference African Americans Blood Glucose Self-Monitoring Chromatography, High Pressure Liquid Methods Electrophoresis Female Immunoassay Methods Patient Identification Point-of-Care Testing Female ab: Hemoglobin Alc (HbAlc) testing can be inaccurate in persons with elevated amounts of Hemoglobin F, or with abnormal hemoglobins found in sickle cell trait, HbC trait and HbE trait. These variants are more prevalent in African and Asian Americans, the same demographic that has an increased risk of diabetes. Variant hemoglobins might cause a false increase or decrease in HbAlc, depending on methodology and manufacturer. Case studies of two African American patients, one with and one without variant hemoglobins, are presented. The major methods used to assay HbAI c, immunoassay, HPLC and boronate affinity are described, and compared for their ability to detect variant hemoglobins. An algorithm is proposed to test new patients using the HPLC method to identify or rule out the presence of the most common variant hemoglobins. Patients with variant hemoglobins can subsequently be assigned to HbAI c methods proven to be accurate in the presence of those hemoglobins. pubtype: Academic Journal doctype: case study tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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