Safety and feasibility of percutaneous vertebroplasty with radioactive (153)Sm PMMA in an animal model.
Purpose: We investigated the safety and feasibility of the combination of samarium-153-ethylenediamine tetramethylene phosphonate ((153)Sm-EDTMP)-incorporated bone cement (BC) with percutaneous vertebroplasty (PVP) in dogs.Methods and Materials: (153)Sm-EDTMP-incorporated BC was prepared by combinin...
| Publicado en: | European Journal of Radiology Vol. 78; no. 2; pp. 296 - 302 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
May2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104905249&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104905249 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0720048X 3S7 jtl: European Journal of Radiology issn: 0720048X maglogo: N pubinfo: dt: May2011 vid: 78 iid: 2 pid: 1004 pub: Elsevier B.V. artinfo: ui: 104905249 104905249 NLM20934823 2011064005 10.1016/j.ejrad.2010.09.002 NLM20934823 104905249 ppf: 296 ppct: 6 formats: tig: atl: Safety and feasibility of percutaneous vertebroplasty with radioactive (153)Sm PMMA in an animal model. aug: au: Lu J Deng J Zhao H Shi M Wang J Zhao L Lu, Jun Deng, Jinglan Zhao, Haitao Shi, Mei Wang, Jing Zhao, Lina affil: Department of Radiotherapy, Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, Xi'an 710032, Shaanxi Province, PR China sug: subj: Bone Cements Pharmacodynamics Kyphoplasty Methods Organometallic Compounds Pharmacodynamics Organophosphorus Compounds Pharmacodynamics Radioisotopes Pharmacodynamics Animal Studies Bone Cements Bone Cements Pharmacokinetics Dogs Magnetic Resonance Imaging Methods Models, Biological Organometallic Compounds Pharmacokinetics Organophosphorus Compounds Pharmacokinetics Pilot Studies Radiography, Interventional Methods Radioisotopes Pharmacokinetics Safety Tomography, Emission-Computed, Single-Photon Methods Tomography, X-Ray Computed Methods ab: Purpose: We investigated the safety and feasibility of the combination of samarium-153-ethylenediamine tetramethylene phosphonate ((153)Sm-EDTMP)-incorporated bone cement (BC) with percutaneous vertebroplasty (PVP) in dogs.Methods and Materials: (153)Sm-EDTMP-incorporated BC was prepared by combining solid (153)Sm-EDTMP and polymethylmethacrylate (PMMA) immediately before PVP. It was then injected into the vertebrae of four healthy mongrel dogs (two males and two females) by PVP under CT guidance. Each dog was subjected to five PVP sessions at a (153)Sm-EDTMP dose of 30-70 mCi. The suppressive effect of local injection of (153)Sm-EDTMP on the hematopoietic system was evaluated through counting of peripheral blood cells. Distribution of (153)Sm-EDTMP-incorporated BC and the status of tissues adjacent to injected vertebrae were evaluated with SPECT, CT and MRI. Histopathology was carried out to assess the influence of PVP on the vertebra and adjacent tissues at the microscopic level.Results: PVP was done successfully, and all dogs exhibited normal behavior and stable physical signs after procedures. (153)Sm-EDTMP-incorporated BC was concentrated mainly in target vertebrae, and the peripheral blood cells remained within normal range. The spinal cord and tissues around BC did not exhibit signs of injury even when the dosage of (153)Sm-EDTMP increased from 30 mCi to 70 mCi.Conclusion: A dose lower than 70 mCi of (153)Sm is safe when it was injected into vertebrae. (153)Sm-EDTMP-incorporated BC did not influence the effect of PVP. This means might strengthen anti-tumor activity locally for vertebra with osseous metastasis without damaging adjacent tissues. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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