Prevalence of Helicobacter pylori and cytotoxin-associated gene A in Iranian patients with non-erosive and erosive reflux disease.
Background: The prevalence of Helicobacter pylori (H. pylori) infection and its virulent strain (cytotoxin-associated gene A: CagA) has not been evaluated in patients with gastroesophageal reflux disease (GERD) subgroups (erosive and non-erosive) in Iran.Aims: This study was conducted to evaluate H....
| Publicado en: | Indian Journal of Medical Sciences Vol. 63; no. 9; pp. 402 - 408 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Scientific Scholar LLC
Sep2009
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104907404&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104907404 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00195359 SV7 jtl: Indian Journal of Medical Sciences issn: 00195359 maglogo: N pubinfo: dt: Sep2009 vid: 63 iid: 9 pid: 56013 pub: Scientific Scholar LLC place: Pittsford, New York artinfo: ui: 104907404 NLM19805919 2010430666 10.4103/0019-5359.56113 NLM19805919 104907404 ppf: 402 ppct: 6 formats: tig: atl: Prevalence of Helicobacter pylori and cytotoxin-associated gene A in Iranian patients with non-erosive and erosive reflux disease. aug: au: Rasmi Y Sadreddini M Shahsavari Z Raeisi S Rasmi, Yousef Sadreddini, Masoud Shahsavari, Zahra Raeisi, Sina affil: Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran sug: subj: Gastroesophageal Reflux Helicobacter Infections Epidemiology Adult Data Analysis Software Descriptive Statistics Endoscopy Enzyme-Linked Immunosorbent Assay Female Human Iran Male Middle Age Prevalence Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: The prevalence of Helicobacter pylori (H. pylori) infection and its virulent strain (cytotoxin-associated gene A: CagA) has not been evaluated in patients with gastroesophageal reflux disease (GERD) subgroups (erosive and non-erosive) in Iran.Aims: This study was conducted to evaluate H. pylori infection and anti-CagA status in GERD.Setting and Design: One hundred fifty-four patients (71 male and 83 female; mean age, 42.6+/- 15.5 years) were evaluated for symptoms--heartburn and acid regurgitation--compatible with GERD.Materials and Methods: The esophagus was diagnosed endoscopically whether it was with erosion (erosive reflux disease, ERD) or without erosion (non-erosive reflux disease, NERD). Rates of anti-H. pylori and anti-CagA-IgG (immunoglobulin G) antibodies were determined for each subject by ELISA. H. pylori was considered by ELISA if the rapid urease test proved positive.Statistical Analysis: anti-H. pylori and anti-CagA statuses were compared in ERD and NERD patients with and without related IgG antibodies. Mean values and P values were calculated using SPSS (version 12).Results: The overall prevalence of H. pylori infection was 75.3% (116/154). Anti-CagA antibody was found in 60.3% (70/116) of infected patients. The prevalence of H. pylori infection in patients with NERD and ERD was 81.2% (56/69) and 70.6% (60/85), respectively (OR=0.56; 95% CI [confidence interval]=0.26-1.20; P=.14). The prevalence of anti-CagA antibody in infected NERD and ERD patients was 58.9% (33/56) and 61.7% (37/60), respectively (OR=1.16; 95% CI=0.49-1.70; P=0.83).Conclusion: The results showed that more than 70% of the patients, either NERD or ERD, acquire H. pylori infection. Anti-CagA antibody is also common in patients with reflux disorders in our community. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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