Effects of compressive residual stress on the morphologic changes of fibroblasts.
Recently, the term tensotaxis was proposed to describe the phenomenon that tensile stress or strain affects cell migration. Even so, less attention has been paid to the effects of compressive stress on cell behavior. In this study, by using an injection-molded method combined with photoelastic techn...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 47; no. 12; pp. 1273 - 1280 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2009
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104908433&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104908433 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Dec2009 vid: 47 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104908433 NLM19639359 2010540924 10.1007/s11517-009-0512-6 NLM19639359 104908433 ppf: 1273 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effects of compressive residual stress on the morphologic changes of fibroblasts. aug: au: Lin SL Yang JC Ho KN Wang CH Yeh CW Huang HM Lin, Shu-Li Yang, Jen-Chang Ho, Kuo-Ning Wang, Chau-Hsiang Yeh, Chien-Wu Huang, Haw-Ming affil: Dental Department, Cathay General Hospital, Taipei, Taiwan sug: subj: Fibroblasts Physiology Cell Culture Techniques Human ab: Recently, the term tensotaxis was proposed to describe the phenomenon that tensile stress or strain affects cell migration. Even so, less attention has been paid to the effects of compressive stress on cell behavior. In this study, by using an injection-molded method combined with photoelastic technology, we developed residual stress gradient-controlled poly-L-lactide discs. After culturing NIH-3T3 fibroblasts on the stress gradient substrate, the cell distributions for high- and low-stress regions were measured and compared. Our results showed that there were significantly more cells in the low-compressive stress region relative to their high-stress analogs (p < 0.05). In addition, NIH-3T3 fibroblasts in the low-compressive stress region expressed more abundant extensive filopodia. These findings provide greater insight into the interaction between cells and substrates, and could serve as a useful reference for connective tissue development and repair. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|