Microwave applicator for hyperthermia treatment on in vivo melanoma model.
In this article, we evaluated a planar microwave applicator for in vivo superficial hyperthermia treatments on small tumors in the mouse mimicking treatments for human neoplasms. The design of the applicator, was challenged by the small dimensions of the tumors and unwanted diffusion of heating in t...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 48; no. 3; pp. 285 - 293 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104908639&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104908639 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Mar2010 vid: 48 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104908639 NLM20033789 2010564240 10.1007/s11517-009-0563-8 NLM20033789 104908639 ppf: 285 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Microwave applicator for hyperthermia treatment on in vivo melanoma model. aug: au: Togni P Vrba J Vannucci L Togni, Paolo Vrba, Jan Vannucci, Luca affil: Department of Electromagnetic Field, Czech Technical University in Prague, Prague, Czech Republic sug: subj: Hyperthermia, Induced Equipment and Supplies Melanoma Therapy Microwaves Therapeutic Use Skin Neoplasms Therapy Animal Studies Equipment Design Hyperthermia, Induced Methods Melanoma Pathology Mice Models, Biological Phantoms, Imaging Skin Neoplasms Pathology ab: In this article, we evaluated a planar microwave applicator for in vivo superficial hyperthermia treatments on small tumors in the mouse mimicking treatments for human neoplasms. The design of the applicator, was challenged by the small dimensions of the tumors and unwanted diffusion of heating in the tumor-bearing animals. The required solution was to limit the penetration of microwaves in the depth of the tissue maintaining the full efficacy of hyperthermia. The study was firstly performed by computer simulations of SAR distribution inside a flat homogeneous phantom, considering various thicknesses of the integrated water bolus. Simulations, validated by the measurements, were also used to evaluate the impedance matching. Further tests were performed on homogeneous agar phantom to simulate the temperature distribution in the biological tissue and to preliminary assess the possible modality and schedule of microwave hyperthermia delivery. The in vivo experiments showed the evidence of direct microwave-induced heating and damage of the melanoma tissue in a range of penetration coherent both with computer simulations and phantom studies. The described approach appears perspective for designing limited-microwave-delivery applicators tailored for treatments of human superficial tumors and pre-tumoral lesions. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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