Ataxin active site determination using spectral distribution of electron ion interaction potentials of amino acids.
Ataxia is a genetic neurological disorder characterised by a neurodegenerative process affecting a motor cortex responsible for balance and coordination. Recently several genes that cause autosomal dominant ataxia development were identified. These abnormal genes share a common ability to produce ab...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 48; no. 4; pp. 303 - 310 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2010
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104909077&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104909077 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Apr2010 vid: 48 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104909077 NLM20148312 2010595638 10.1007/s11517-010-0587-0 NLM20148312 104909077 ppf: 303 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Ataxin active site determination using spectral distribution of electron ion interaction potentials of amino acids. aug: au: Pirogova E Vojisavljevic V Hernández Cáceres JL Cosic I Pirogova, E Vojisavljevic, V Cáceres, J L Hernández Cosic, I affil: School of Electrical and Computer Engineering, RMIT University, Melbourne, VIC, Australia sug: subj: Ataxia Metabolism Models, Theoretical Nerve Tissue Proteins Proteins Amino Acids Nerve Tissue Proteins Physiology Proteins Physiology Signal Processing, Computer Assisted Biochemical Phenomena ab: Ataxia is a genetic neurological disorder characterised by a neurodegenerative process affecting a motor cortex responsible for balance and coordination. Recently several genes that cause autosomal dominant ataxia development were identified. These abnormal genes share a common ability to produce abnormal ataxin proteins that can affect nerve cells in the cerebellum and spinal cord. Here, using the Resonant Recognition Model (RRM) based on signal processing, we analysed ataxin proteins and identified the characteristic features corresponding to their biological activities. The RRM is a physico-mathematical model developed for analysis of protein interactions. By incorporating Smoothed Pseudo Wigner-Ville distribution (SPWV) in the RRM, we can define the active regions along the protein molecule. The results showed that our computational predictions correspond closely with the experimentally identified locations of the active/binding sites for ataxin-1 and ataxin-3 protein groups. The results obtained provide a valuable insight into the functional performance of ataxin proteins. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|