Intraoperative touch imprint cytology of sentinel lymph nodes in breast cancer: experience at a tertiary care center in Mexico.
Background: Sentinel lymph node (SLN) biopsy in patients with breast cancer has emerged as a conservative and promising procedure. One of the most important issues is the intraoperative evaluation of the SLN with a high degree of accuracy by frozen section and/or imprint cytology. The objective of t...
| Publicado en: | Medical Oncology Vol. 27; no. 2; pp. 233 - 237 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Jun2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104909972&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104909972 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13570560 DZI jtl: Medical Oncology issn: 13570560 maglogo: N pubinfo: dt: Jun2010 vid: 27 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104909972 104909972 NLM19296239 2010641053 10.1007/s12032-009-9197-9 NLM19296239 104909972 ppf: 233 ppct: 4 formats: tig: atl: Intraoperative touch imprint cytology of sentinel lymph nodes in breast cancer: experience at a tertiary care center in Mexico. aug: au: Pérez-Sánchez VM Vela-Chávez TA Villarreal-Colin P Bargalló-Rocha E Ramírez-Ugalde MT Munoz-Gonzalez D Zeichner-Gancz I Pérez-Sánchez, V M Vela-Chávez, T A Villarreal-Colin, P Bargalló-Rocha, E Ramírez-Ugalde, M T Munoz-Gonzalez, D Zeichner-Gancz, I affil: Pathology Department, Instituto Nacional de Cancerología México, Ave San Fernando 22, Tlalpan, México DF, México sug: subj: Breast Neoplasms Diagnosis Breast Neoplasms Surgery Intraoperative Care Methods Sentinel Lymph Node Biopsy Methods Touch Adult Aged Cytological Techniques Female Human Mexico Middle Age Randomized Controlled Trials Specimen Handling Methods Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female ab: Background: Sentinel lymph node (SLN) biopsy in patients with breast cancer has emerged as a conservative and promising procedure. One of the most important issues is the intraoperative evaluation of the SLN with a high degree of accuracy by frozen section and/or imprint cytology. The objective of this study was to test the ability of intraoperative touch imprint cytology (ITIC) to predict metastasis on SLN.Methods: SLNs were freshly examined, bisected in <0.5 cm or serially sectioned at 2 mm intervals on the long axis. Each surface of the section was touched on the glass slide, and stained. Results of ITIC were compared with permanent sections. Sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), and accuracy (Acc) were calculated. False negatives were reviewed.Results: We analyzed 179 SLN from 110 patients. The comparison between ITIC and final results of the SLN showed 139 (77.6%) true negative imprints, and 28 (15.6%) true positive. There were 12 (6.70%) false negative (FN) imprints which included 6 macrometastases, 3 micrometastases, and 3 isolated tumor cells. Re-screening after the definitive results of false negative imprints showed again 10 negative imprints, one with two groups of cells and one with multiple groups of cells. The overall Se was 70% (73.6% for micro/macrometastases and 82.3% for macrometastases), Sp and PPV were 100% in all cases. NPV was 92.1% overall (93.4% micro/macrometastases and 96% in macrometastases).Global accuracy was 93.3% (94.4% for micro/macrometastases and 96% for in macrometastases).Conclusions: ITIC is excellent to detect macrometastases, however, it fails to detect micrometastases. False negative imprints for macrometastases are mainly due to sampling error. The immediate availability, low cost, high Sp, PPV, preservation of the lymph node for histopathologic examination, avoiding of a second surgery are the major advantages of intraoperative evaluation of SLN. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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