Whole-body diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient mapping for staging patients with diffuse large B-cell lymphoma.
Objective: To design a whole-body MR protocol using exclusively diffusion-weighted imaging (DWI) with respiratory gating and to assess its value for lesion detection and staging in patients with diffuse large B-cell lymphoma (DLBCL), with integrated FDG PET/CT as the reference standard.Methods: Fift...
| Publicado en: | European Radiology Vol. 20; no. 8; pp. 2027 - 2039 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Aug2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104912177&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104912177 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2010 vid: 20 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104912177 51989444 NLM20309558 2010710000 10.1007/s00330-010-1758-y NLM20309558 104912177 ppf: 2027 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Whole-body diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient mapping for staging patients with diffuse large B-cell lymphoma. aug: au: Lin C Luciani A Itti E El-Gnaoui T Vignaud A Beaussart P Lin SJ Belhadj K Brugières P Evangelista E Haioun C Meignan M Rahmouni A Lin, Chieh Luciani, Alain Itti, Emmanuel El-Gnaoui, Taoufik Vignaud, Alexandre Beaussart, Pauline Lin, Shih-jui affil: Imagerie Médicale, AP-HP, Groupe Henri-Mondor Albert-Chenevier, CHU Henri Mondor, Créteil, France sug: subj: Magnetic Resonance Imaging Methods Image Interpretation, Computer Assisted Methods Lymphoma, B-Cell Pathology Diagnostic Imaging Methods Adult Aged Human Image Enhancement Methods Middle Age Neoplasm Staging Reproducibility of Results Sensitivity and Specificity Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years ab: Objective: To design a whole-body MR protocol using exclusively diffusion-weighted imaging (DWI) with respiratory gating and to assess its value for lesion detection and staging in patients with diffuse large B-cell lymphoma (DLBCL), with integrated FDG PET/CT as the reference standard.Methods: Fifteen patients underwent both whole-body DWI (b = 50, 400, 800 s/mm(2)) and PET/CT for pretreatment staging. Lymph node and organ involvement were evaluated by qualitative and quantitative image analysis, including measurement of the mean apparent diffusion coefficient (ADC).Results: A total of 296 lymph node regions in the 15 patients were analysed. Based on International Working Group size criteria alone, DWI findings matched PET/CT findings in 277 regions (94%) (kappa score = 0.85, P < 0.0001), yielding sensitivity and specificity for DWI lymph node involvement detection of 90% and 94%. Combining visual ADC analysis with size measurement increased DWI specificity to 100% with 81% sensitivity. For organ involvement, the two techniques agreed in all 20 recorded organs (100%). All involved organ lesions showed restricted diffusion. Ann Arbor stages agreed in 14 (93%) of the 15 patients.Conclusion: Whole-body DWI with ADC analysis can potentially be used for lesion detection and staging in patients with DLBCL. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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