Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm.
Capsule: HLA-B associated transcript (BAT) 2, 3, and 5 polymorphisms and haplotypes are associated with Kawasaki disease (KD) and coronary artery aneurysm (CAA) formations.Objective: KD, an acute vasculitis with unknown etiology, involves a complex interaction of immuno-inflammatory process, cytokin...
| Published in: | Journal of Clinical Laboratory Analysis Vol. 24; no. 4; pp. 262 - 269 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Wiley-Blackwell
2010
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104913394&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104913394 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08878013 OCK jtl: Journal of Clinical Laboratory Analysis issn: 08878013 maglogo: Y pubinfo: dt: 2010 vid: 24 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104913394 NLM20626023 2010725740 10.1002/jcla.20409 NLM20626023 104913394 ppf: 262 ppct: 7 formats: tig: atl: Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm. aug: au: Hsieh YY Lin YJ Chang CC Chen DY Hsu CM Lo MM Hsu KH Tsai FJ Hsieh, Yao-Yuan Lin, Ying-Ju Chang, Chi-Chen Chen, Da-Yuan Hsu, Chin-Mu Wang, Yu-Kuo Hsu, Kung-Hao Tsai, Fuu-Jen affil: School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan sug: subj: Coronary Aneurysm HLA Antigens Proteins Mucocutaneous Lymph Node Syndrome Chi Square Test Child Child, Preschool Chromosomes Female Genetic Markers Disease Susceptibility Genotype Human Male Polymorphism, Genetic Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Capsule: HLA-B associated transcript (BAT) 2, 3, and 5 polymorphisms and haplotypes are associated with Kawasaki disease (KD) and coronary artery aneurysm (CAA) formations.Objective: KD, an acute vasculitis with unknown etiology, involves a complex interaction of immuno-inflammatory process, cytokines activation, and genetic factors. We aimed to investigate if genetic variants of human lymphocyte antigen (HLA)-BAT2, 3, and 5 (BAT2, 3, and 5) could be used as markers of susceptibility in KD and CAA.Methods: Individuals were divided into three groups: (1) normal controls; (2) KD with CAA; and (3) KD without CAA. Polymorphisms for BAT2 (-8671, 16483), BAT3 (8854, 2-24), and BAT5 (22655, 9569) were genotyped by PCR system with TaqMan allelic discrimination assay. Genotype/allelic frequencies and haplotypes (BAT2(-8671)-BAT2(16483)-BAT3(8854)-BAT3(2-24)-BAT5(22655)-BAT5(9569)) in each group were compared.Results: Genotype distribution and allele frequency of BAT2 -8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms in each group were significantly different. BAT2 -8671*G, BAT3 8854*C, BAT5 22655*C, and 9569*A-related genotypes and alleles are correlated with the developments of KD and CAA. BAT haplotypes of ATTGTG and ATCATG are associated with higher susceptibilities of KD with CAA susceptibility.Conclusion: BAT2 -8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms as well as BAT haplotypes (ATTGTG and ATCATG) might be associated with higher KD susceptibility and CAA formation. HLA-B region polymorphisms might contribute to the pathogenesis of KD and CAA. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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