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Squamous cell carcinoma of the head and neck: diffusion-weighted MR imaging for prediction and monitoring of treatment response.

Objective: To investigate the role of diffusion-weighted imaging (DWI) in predicting and monitoring chemoradiotherapy response in head and neck squamous cell carcinoma (HNSCC).Methods: Diffusion-weighted imaging was performed pre-treatment (n = 50), intra-treatment (n = 41) and post-treatment (n = 2...

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Published in:European Radiology Vol. 20; no. 9; pp. 2213 - 2221
Main Authors: King AD, Mo FK, Yu KH, Yeung DK, Zhou H, Bhatia KS, Tse GM, Vlantis AC, Wong JK, Ahuja AT, King, Ann D, Mo, Frankie K F, Yu, Kwok-Hung, Yeung, David K W, Zhou, Hua, Bhatia, Kunwar S, Tse, Gary M K, Vlantis, Alexander C, Wong, Jeffrey K T, Ahuja, Anil T
Format: research Journal Article
Published: Springer Nature Sep2010
Online Access:View this record in EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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        atl: Squamous cell carcinoma of the head and neck: diffusion-weighted MR imaging for prediction and monitoring of treatment response.
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          King AD
          Mo FK
          Yu KH
          Yeung DK
          Zhou H
          Bhatia KS
          Tse GM
          Vlantis AC
          Wong JK
          Ahuja AT
          King, Ann D
          Mo, Frankie K F
          Yu, Kwok-Hung
          Yeung, David K W
          Zhou, Hua
          Bhatia, Kunwar S
          Tse, Gary M K
          Vlantis, Alexander C
          Wong, Jeffrey K T
          Ahuja, Anil T
        affil: Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, Prince of Wales Hospital, Shatin, The Chinese University of Hong Kong, New Territories, Hong Kong, SAR, China
      sug:
        subj:
          Magnetic Resonance Imaging Methods
          Outcome Assessment Methods
          Aged
          Carcinoma, Squamous Cell
          Female
          Head and Neck Neoplasms
          Human
          Male
          Middle Age
          Prognosis
          Reproducibility of Results
          Sensitivity and Specificity
          Treatment Outcomes
          Aged: 65+ years
          Middle Aged: 45-64 years
          Female
          Male
      ab: Objective: To investigate the role of diffusion-weighted imaging (DWI) in predicting and monitoring chemoradiotherapy response in head and neck squamous cell carcinoma (HNSCC).Methods: Diffusion-weighted imaging was performed pre-treatment (n = 50), intra-treatment (n = 41) and post-treatment (n = 20). Apparent diffusion coefficient (ADC) values were correlated with locoregional failure (LF).Results: Locoregional failure occurred in 20/50 (40%) patients. A significant correlation was found between LF and post-treatment ADC (p = 0.02) but not pre- or intra-treatment ADC. Serial change in ADC was even more significant (p = 0.00001), using a fall in ADC early (pre- to intra-treatment) or late (intra- to post-treatment) to indicate LF, achieved 100% specificity, 80% sensitivity and 90% accuracy.Conclusions: Single ADC measurements pre- or intra-treatment did not predict response, but ADC post-treatment was a marker for LF. Serial change in ADC was an even stronger marker, when using an early or late treatment fall in ADC to identify LF.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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