Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results.
Background: Xenon ventilation CT using dual-source and dual-energy technique is a recently introduced, promising functional lung imaging method. To expand its clinical applications evidence of additional diagnostic value of xenon ventilation CT over conventional chest CT is required.Objective: To ev...
| Publicado en: | Pediatric Radiology Vol. 40; no. 9; pp. 1490 - 1498 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104915753&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104915753 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Sep2010 vid: 40 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104915753 NLM20411254 2010749632 10.1007/s00247-010-1645-3 NLM20411254 104915753 ppf: 1490 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results. aug: au: Goo HW Yang DH Hong SJ Yu J Kim BJ Seo JB Chae EJ Lee J Krauss B Goo, Hyun Woo Yang, Dong Hyun Hong, Soo-Jong Yu, Jinho Kim, Byoung-Ju Seo, Joon Beom Chae, Eun Jin Lee, Jeongjin Krauss, Bernhard affil: Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea sug: subj: Bronchiolitis Obliterans Radiography Contrast Media Administration and Dosage Contrast Media Diagnostic Use Tomography, X-Ray Computed Methods Gases Diagnostic Use Administration, Inhalation Adolescence Bronchiolitis Obliterans Physiopathology Child Female Male Radiographic Image Interpretation, Computer-Assisted Respiratory Function Tests Gases Administration and Dosage Adolescent: 13-18 years Child: 6-12 years Female Male ab: Background: Xenon ventilation CT using dual-source and dual-energy technique is a recently introduced, promising functional lung imaging method. To expand its clinical applications evidence of additional diagnostic value of xenon ventilation CT over conventional chest CT is required.Objective: To evaluate the usefulness of xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans (BO).Materials and Methods: Seventeen children (age 7-18 years; 11 boys) with BO underwent xenon ventilation CT using dual-source and dual-energy technique. Xenon and CT density values were measured in normal and hyperlucent lung regions on CT and were compared between the two regions. Volumes of hyperlucent regions and ventilation defects were calculated with thresholds determined by visual and histogram-based analysis. Indexed volumes of hyperlucent lung regions and ventilation defects were correlated with pulmonary function test results. Effective doses of xenon CT were calculated.Results: Xenon (14.6 +/- 6.4 HU vs 26.1 +/- 6.5 HU; P < 0.001) and CT density (-892.8 +/- 25.4 HU vs -812.3 +/- 38.7 HU; P < 0.001) values were significantly lower in hyperlucent regions than in normal lung regions. Xenon and CT density values showed significant positive correlation for the entire lung in 16 children (gamma = 0.55 +/- 0.17, P < 0.001 or =0.017) and for hyperlucent regions in 13 children (gamma = 0.44 +/- 0.16, P < 0.001 or =0.001-0.019). Indexed volumes and volume percentages of hyperlucent lung regions and ventilation defects showed strong negative correlations with forced expiratory volume [FEV1, (gamma = -0.64--0.85, P <or= 0.006)], FEV1/forced vital capacity [FVC, (gamma = -0.63--0.84, P <or= 0.008), and forced midexpiratory flow rate [FEF(25-75), (gamma = -0.68--0.88, P <or= 0.002). Volume percentages of xenon ventilation defects (35.0 +/- 16.4%) were not significantly different from those of hyperlucent lung regions (38.2 +/- 18.6%). However, mismatches between the volume percentages were variable up to 21.4-33.3%. Mean effective dose of xenon CT was 1.9 +/- 0.5 mSv.Conclusion: In addition to high-resolution anatomic information, xenon ventilation CT using dual-source and dual-energy technique demonstrates impaired regional ventilation and its heterogeneity accurately in children with BO without additional radiation exposure. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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