Reciprocal powered time model for release kinetic analysis of ibuprofen solid dispersions in oleaster powder, microcrystalline cellulose and crospovidone.
Purpose: A physically sound derivation for reciprocal power time (RPT) model for kinetic of drug release is given. In order to enhance ibuprofen dissolution, its solid dispersions (SDs) prepared by cogrinding technique using crospovidone (CP), microcrystalline cellulose (MC) and oleaster powder (OP)...
| Publicado en: | Journal of Pharmacy & Pharmaceutical Sciences Vol. 13; no. 2; pp. 152 - 162 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Frontiers Media S.A.
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104921946&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104921946 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14821826 1CUO jtl: Journal of Pharmacy & Pharmaceutical Sciences issn: 14821826 maglogo: N pubinfo: dt: 2010 vid: 13 iid: 2 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 104921946 104921946 NLM20816002 2010781938 NLM20816002 104921946 ppf: 152 ppct: 10 formats: tig: atl: Reciprocal powered time model for release kinetic analysis of ibuprofen solid dispersions in oleaster powder, microcrystalline cellulose and crospovidone. aug: au: Mohammadi G Barzegar-Jalali M Valizadeh H Nazemiyeh H Barzegar-Jalali A Siahi Shadbad MR Adibkia K Zare M Mohammadi, Ghobad Barzegar-Jalali, Mohammad Valizadeh, Hadi Nazemiyeh, Hossein Barzegar-Jalali, Azim Siahi Shadbad, Mohammad Reza Adibkia, Khosro Zare, Masoud affil: Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran sug: subj: Antiinflammatory Agents, Non-Steroidal Drug Delivery Systems Ibuprofen Models, Theoretical Antiinflammatory Agents, Non-Steroidal Administration and Dosage Cellulose Crystallization Plants Fruit Ibuprofen Administration and Dosage Particle Size Plant Extracts Povidone Powders Solubility Time Factors ab: Purpose: A physically sound derivation for reciprocal power time (RPT) model for kinetic of drug release is given. In order to enhance ibuprofen dissolution, its solid dispersions (SDs) prepared by cogrinding technique using crospovidone (CP), microcrystalline cellulose (MC) and oleaster powder (OP) as a novel carrier and the model applied to the drug release data.Methods: The drug cogrounds with the carriers were prepared and subjected to the dissolution studies. For elucidation of observed in vitro differences, FT-IR spectroscopy, X-ray diffraction patterns, DSC thermograms and laser particle size measurement were conducted.Results: All drug release data fitted very well to newly derived RPT model. The efficiency of the carriers for dissolution enhancement was in the order of: CP>OP>MC. The corresponding release kinetic parameter derived from the model, t50% (time required for 50% dissolution) for the carrier to drug ratio 2:1 were 2.7, 10.2 and 12.6 min, respectively. The efficiency of novel carrier, OP, was between CP and MC. FT-IR showed no interaction between the carriers and drug. The DSC thermograms and X-ray diffraction patterns revealed a slight reduced crystallinty in the SDs. Also grinding reduced mean particle size of drug from 150.7 to 44.4 microm.Conclusions: An improved derivation for RPT model was provided which the parameter of the model, t50%, unlike to previous derivations was related to the most important property of the drug i.e. its solubility. The model described very well drug release kinetics from the solid dispersions. Cogrinding was an effective technique in enhancing dissolution rate of ibuprofen. Elaeagnus angostifolia fruit powder was suggested as a novel potential hydrophilic carrier in preparing solid dispersion of ibuprofen. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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