Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow.
Objective: To retrospectively investigate enhancement patterns of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced MRI in relation to histological grading and portal blood flow.Methods: Sixty-nin...
| Published in: | European Radiology Vol. 20; no. 10; pp. 2405 - 2414 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Oct2010
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104923999&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104923999 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Oct2010 vid: 20 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104923999 53703853 NLM20490505 2010796847 10.1007/s00330-010-1812-9 NLM20490505 104923999 ppf: 2405 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow. aug: au: Kogita S Imai Y Okada M Kim T Onishi H Takamura M Fukuda K Igura T Sawai Y Morimoto O Hori M Nagano H Wakasa K Hayashi N Murakami T Kogita, Sachiyo Imai, Yasuharu Okada, Masahiro Kim, Tonsok Onishi, Hiromitsu affil: Department of Gastroenterology, Ikeda Municipal Hospital, 3-1-18, Johnan, Ikeda, Osaka, 563-8510, Japan sug: subj: Carcinoma, Hepatocellular Metabolism Contrast Media Pharmacodynamics Liver Neoplasms Metabolism Magnetic Resonance Imaging Methods Aged Aged, 80 and Over Carcinoma, Hepatocellular Diagnosis Diagnostic Imaging Methods Female Human Liver Neoplasms Diagnosis Male Oncology Methods Middle Age Portal Vein Pathology Retrospective Design Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objective: To retrospectively investigate enhancement patterns of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced MRI in relation to histological grading and portal blood flow.Methods: Sixty-nine consecutive patients with 83 histologically proven HCCs and DNs were studied. To assess Gd-EOB-DTPA uptake, we calculated the EOB enhancement ratio, which is the ratio of the relative intensity of tumorous lesion to surrounding nontumorous area on hepatobiliary phase images (post-contrast EOB ratio) to that on unenhanced images (pre-contrast EOB ratio). Portal blood flow was evaluated by CT during arterial portography.Results: Post-contrast EOB ratios significantly decreased as the degree of differentiation declined in DNs (1.00 ± 0.14) and well, moderately and poorly differentiated HCCs (0.79 ± 0.19, 0.60 ± 0.27, 0.49 ± 0.10 respectively). Gd-EOB-DTPA uptake, assessed by EOB enhancement ratios, deceased slightly in DNs and still more in HCCs, while there was no statistical difference in the decrease between different histological grades of HCC. Reductions in portal blood flow were observed less frequently than decreases in Gd-EOB-DTPA uptake in DNs and well-differentiated HCCs.Conclusions: Reduced Gd-EOB-DTPA uptake might be an early event of hepatocarcinogenesis, preceding portal blood flow reduction. The hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI may help estimate histological grading, although difficulties exist in differentiating HCCs from DNs. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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