Health-related quality of life and cognitive outcomes among child and adolescent survivors of leukemia.
Purpose: Long-term survival of childhood leukemia has become a reality with treatment advancement; hence, the need to assess the survivors' health-related quality of life (HRQL) is essential. Although a growing number of Western studies have documented the considerable impact of diagnosis and treatm...
| Publicado en: | Supportive Care in Cancer Vol. 18; no. 12; pp. 1581 - 1588 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104933424&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104933424 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Dec2010 vid: 18 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104933424 54567705 NLM19949961 2010836997 10.1007/s00520-009-0781-5 NLM19949961 104933424 ppf: 1581 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Health-related quality of life and cognitive outcomes among child and adolescent survivors of leukemia. aug: au: Chiou SS Jang RC Liao YM Yang P Chiou, Shyh-Shin Jang, Ren-Chin Liao, Yu-Mei Yang, Pinchen affil: Department of Pediatrics, College of Medicine, Kaohsiung Medical University and Kaohsiung Medical University Hospital, Kaohsiung, Taiwan sug: subj: Cognition Disorders Epidemiology Leukemia, Lymphocytic, Acute Psychosocial Factors Survivors Psychosocial Factors Adolescence Child Child, Preschool Clinical Assessment Tools Cognition Disorders Etiology Combined Modality Therapy Adverse Effects Female Human Infant Leukemia, Lymphocytic, Acute Complications Leukemia, Lymphocytic, Acute Epidemiology Leukemia, Lymphocytic, Acute Therapy Male Neoplasm Recurrence, Local Prevention and Control Prospective Studies Quality of Life Questionnaires Sickness Impact Profile Survival Taiwan Adolescent: 13-18 years Child: 6-12 years Child, Preschool: 2-5 years Infant: 1-23 months Female Male ab: Purpose: Long-term survival of childhood leukemia has become a reality with treatment advancement; hence, the need to assess the survivors' health-related quality of life (HRQL) is essential. Although a growing number of Western studies have documented the considerable impact of diagnosis and treatment on HRQL in pediatric leukemia survivors, little finding has been reported in non-Western developing countries.Methods: We used a previously validated 14-dimensional questionnaire, Child Health Questionnaire 50-item Parent Form (CHQ-PF 50), to examine the perceived HRQL of 32 child/adolescent survivors, currently aged 13.17 ± 2.49 years, who had experienced first complete continuous remission from leukemia for at least 3 years. The HRQL status was compared with that obtained from community subjects (N = 154) and survivors' nonadult siblings (N = 30). Intelligence quotients (IQ) and computerized neuropsychological assessments were performed for subjects.Results: The HRQL of leukemia survivors was noted to be worse than that of community children and nonadult siblings as reflected by significantly lower scores in both the physical summary and the psychosocial summary score of CHQ-PF 50. 15.6% of the survivors had impaired intelligence (estimated IQ below 70). 27.8% of the adolescents were impaired in the cognitive domains as assessed by neuropsychological tests.Conclusions: In this Taiwanese single institution experience, pediatric leukemia survivors carried a morbidity burden into their teen years as reflected by worse HRQL than controls. These findings may guide the support required by this population. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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