High-fidelity computer models for prospective treatment planning of radiofrequency ablation with in vitro experimental correlation.
Purpose: To evaluate the accuracy of computer simulation in predicting the thermal damage region produced by a radiofrequency (RF) ablation procedure in an in vitro perfused bovine liver model. The thermal dose end point in the liver model is used to assess quantitatively computer prediction for use...
| Publicado en: | Journal of Vascular & Interventional Radiology Vol. 21; no. 11; pp. 1725 - 1733 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Nov2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104935816&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104935816 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10510443 1FPN jtl: Journal of Vascular & Interventional Radiology issn: 10510443 maglogo: N pubinfo: dt: Nov2010 vid: 21 iid: 11 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 104935816 NLM20920840 2010843372 10.1016/j.jvir.2010.07.022 NLM20920840 PMC2966506 104935816 ppf: 1725 ppct: 8 formats: tig: atl: High-fidelity computer models for prospective treatment planning of radiofrequency ablation with in vitro experimental correlation. aug: au: Fuentes D Cardan R Stafford RJ Yung J Dodd GD 3rd Feng Y Fuentes, David Cardan, Rex Stafford, R Jason Yung, Joshua Dodd, Gerald D 3rd Feng, Yusheng affil: Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA sug: subj: Catheter Ablation Computer Simulation Liver Surgery Models, Biological Therapy, Computer Assisted Algorithms Animal Studies Cattle Finite Element Analysis Liver Pathology Perfusion Time Factors ab: Purpose: To evaluate the accuracy of computer simulation in predicting the thermal damage region produced by a radiofrequency (RF) ablation procedure in an in vitro perfused bovine liver model. The thermal dose end point in the liver model is used to assess quantitatively computer prediction for use in prospective treatment planning of RF ablation procedures.Materials and Methods: Geometric details of the tri-cooled tip electrode were modeled. The resistive heating of a pulsed voltage delivery was simulated in four dimensions using finite element models (FEM) implemented on high-performance parallel computing architectures. A range of physically realistic blood perfusion parameters, 3.6-53.6 kg/sec/m(3), was considered in the computer model. An Arrhenius damage model was used to predict the thermal dose. Dice similarity coefficients (DSC) were the metric of comparison between computational predictions and T1-weighted contrast-enhanced images of the damage obtained from a RF procedure performed on an in vitro perfused bovine liver model.Results: For a perfusion parameter greater than 16.3 kg/sec/m(3), simulations predict the temporal evolution of the damaged volume is perfusion limited and will reach a maximum value. Over a range of physically meaningful perfusion values, 16.3-33.1 kg/sec/m(3), the predicted thermal dose reaches the maximum damage volume within 2 minutes of the delivery and is in good agreement (DSC > 0.7) with experimental measurements obtained from the perfused liver model.Conclusions: As measured by the computed volumetric DSC, computer prediction accuracy of the thermal dose shows good correlation with ablation lesions measured in vitro in perfused bovine liver models over a range of physically realistic perfusion values. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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