Successful treatment of Fusarium solani ecthyma gangrenosum in a patient affected by leukocyte adhesion deficiency type 1 with granulocytes transfusions.
Background: Ecthyma gangrenosum (EG) manifests as a skin lesion affecting patients suffering extreme neutropenia and is commonly associated with Pseudomonas aeruginosa in immunocompromised patients. Leukocyte adhesion deficiency I (LAD I) which count among primary immunodeficiency syndromes of the i...
| Publicado en: | BMC Dermatology Vol. 10; pp. 10 - 11 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | case study Journal Article |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104935977&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104935977 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14715945 1CHG jtl: BMC Dermatology issn: 14715945 maglogo: N pubinfo: dt: 2010 vid: 10 pid: 24147 pub: BioMed Central artinfo: ui: 104935977 NLM20929531 2010844652 10.1186/1471-5945-10-10 NLM20929531 PMC2959010 104935977 ppf: 10 ppct: 1 formats: tig: atl: Successful treatment of Fusarium solani ecthyma gangrenosum in a patient affected by leukocyte adhesion deficiency type 1 with granulocytes transfusions. aug: au: Mellouli F Ksouri H Barbouche R Maamer M Hamed LB Hmida S Hassen AB Béjaoui M Mellouli, Fethi Ksouri, Habib Barbouche, Ridha Maamer, Mongi Hamed, Leila Ben Hmida, Slama Hassen, Assia Ben Béjaoui, Mohamed affil: Service d'Immuno-Hématologie Pédiatrique, Centre National de Greffe de Moelle Osseuse, 2 rue Jebel Lakdhar, Tunis, Tunisia sug: subj: Pyoderma Immunology Pyoderma Microbiology Pyoderma Therapy Fungi Gangrene Immunology Gangrene Microbiology Gangrene Therapy Granulocytes Transplantation Child Female Immunocompromised Host Immunologic Deficiency Syndromes Complications Immunologic Deficiency Syndromes Immunology Neutropenia Complications Neutropenia Immunology Child: 6-12 years Female ab: Background: Ecthyma gangrenosum (EG) manifests as a skin lesion affecting patients suffering extreme neutropenia and is commonly associated with Pseudomonas aeruginosa in immunocompromised patients. Leukocyte adhesion deficiency I (LAD I) which count among primary immunodeficiency syndromes of the innate immunity, is an autosomal recessive disorder characterized in its severe phenotype by a complete defect in CD18 expression on neutrophils, delayed cord separation, chronic skin ulcers mainly due to recurrent bacterial and fungal infections, leucocytosis with high numbers of circulating neutrophils and an accumulation of abnormally low number of neutrophils at sites of infection.Case Presentation: We report at our knowledge the first case of a child affected by LAD-1, who experienced during her disease course a multi-bacterial and fungal EG lesion caused by fusarium solani. Despite targeted antibiotics and anti-fungi therapy, the lesion extended for as long as 18 months and only massive granulocytes pockets transfusions in association with G-CSF had the capacity to cure this lesion.Conclusion: We propose that granulocytes pockets transfusions will be beneficial to heal EG especially in severely immunocompromised patients. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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