The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people.
What is known and objective: Genetic polymorphism of interleukin (IL)-1β and IL-1 receptor antagonist (IL-1rα) are associated with efficacy of acid suppression, whereas cytochrome P (CYP) 2C19 polymorphism influences the metabolism of proton pump inhibitor family. Thus, CYP2C19 and IL-1 polymorphism...
| Published in: | Journal of Clinical Pharmacy & Therapeutics Vol. 35; no. 6; pp. 713 - 723 |
|---|---|
| Main Authors: | , , , , |
| Format: | clinical trial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Dec2010
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104938330&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104938330 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Dec2010 vid: 35 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104938330 104938330 2010851606 10.1111/j.1365-2710.2009.01140.x NLM21054464 104938330 ppf: 713 ppct: 10 formats: fmt: @attributes: type: P tig: atl: The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people. aug: au: Zhang L Mei Q Li QS Hu YM Xu JM affil: Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University sug: subj: Polymorphism, Genetic Drug Therapy, Combination Helicobacter Infections Drug Therapy Proton Pump Inhibitors Metabolism Rabeprazole Sodium Therapeutic Use Omeprazole Therapeutic Use Interleukin 1 Antagonists and Inhibitors Hemeproteins China Human Male Female Adult Middle Age Clinical Trials Random Assignment Treatment Outcomes Amoxicillin Therapeutic Use Clarithromycin Therapeutic Use Prospective Studies Rabeprazole Sodium Administration and Dosage Omeprazole Administration and Dosage Peptic Ulcer Drug Therapy Academic Medical Centers Adolescence Aged Genotype Polymerase Chain Reaction Sequence Analysis Chi Square Test Fisher's Exact Test Mann-Whitney U Test Data Analysis Software Interviews Adverse Drug Event Confidence Intervals Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Adolescent: 13-18 years Aged: 65+ years Male Female ab: What is known and objective: Genetic polymorphism of interleukin (IL)-1β and IL-1 receptor antagonist (IL-1rα) are associated with efficacy of acid suppression, whereas cytochrome P (CYP) 2C19 polymorphism influences the metabolism of proton pump inhibitor family. Thus, CYP2C19 and IL-1 polymorphisms may affect the efficacy of H. pylori eradication therapy. We compared the efficacies of omeprazole and rabeprazole on eradication of H. pylori in relation to CYP2C19, IL-1B and IL-1RN genotypes in Chinese people. Methods: Two hundred and forty Chinese with peptic ulcer disease were randomly assigned to the following regimens: amoxicillin and clarithromycin together with omeprazole (OAC) or rabeprazole (RAC). CYP2C19*2 and *3, IL1B-511, IL1B-31, IL1B+ 3954 and intron 2 of the IL-1RN genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Results: The intention-to-treat-based cure rate of the OAC regimen was significantly lower than that of the RAC regimen in the CYP2C19 wild-type homozygotes ( P = 0·014). No significant differences in the cure rates were observed among the IL-1RN and the IL-1B genotype groups. What is new and conclusions: The rabeprazole-based triple regimen was better than the omeprazole in Chinese patients with the CYP2C19 extensive metabolizer genotype. The effectiveness of the PPI/AC regimen is unrelated to IL-1B and IL1-RN genetic polymorphism. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|