Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions.
The functional link between genetic alteration and behavioral end-state is rarely straightforward and never linear. Cases where neurodevlopmental conditions defined by a distinct genetic etiology share behavioral phenotypes are exemplary, as is the case for autism and Fragile X Syndrome (FXS). In th...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 40; no. 12; pp. 1531 - 1541 |
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| Autores principales: | , , , , |
| Formato: | tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104942406&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104942406 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Dec2010 vid: 40 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104942406 55167059 10.1007/s10803-010-1109-5 NLM20886276 104942406 ppf: 1531 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Using Perceptual Signatures to Define and Dissociate Condition-Specific Neural Etiology: Autism and Fragile X Syndrome as Model Conditions. aug: au: Bertone A Hanck J Kogan C Chaudhuri A Cornish K affil: McGill Child Laboratory for Research and Education in Developmental Disorders, McGill University, Montreal Canada sug: subj: Autism Spectrum Disorder Physiopathology Fragile X Syndrome Physiopathology Genotype Neural Pathways Autism Spectrum Disorder Familial and Genetic Fragile X Syndrome Familial and Genetic Conceptual Framework ab: The functional link between genetic alteration and behavioral end-state is rarely straightforward and never linear. Cases where neurodevlopmental conditions defined by a distinct genetic etiology share behavioral phenotypes are exemplary, as is the case for autism and Fragile X Syndrome (FXS). In this paper and its companion paper, we propose a method for assessing the functional link between genotype and neural alteration across these target conditions by comparing their perceptual signatures. In the present paper, we discuss how such signatures can be used to (1) define and differentiate various aspects of neural functioning in autism and FXS, and subsequently, (2) to infer candidate causal (genetic) mechanisms based on such signatures (see companion paper, this issue). pubtype: Academic Journal doctype: tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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