Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling.
We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performanc...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 40; no. 12; pp. 1541 - 1549 |
|---|---|
| Autores principales: | , , , , |
| Formato: | tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2010
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104942408&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104942408 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Dec2010 vid: 40 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104942408 55167060 10.1007/s10803-010-1110-z NLM20872060 104942408 ppf: 1541 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Associating Neural Alterations and Genotype in Autism and Fragile X Syndrome: Incorporating Perceptual Phenotypes in Causal Modeling. aug: au: Bertone A Hanck J Kogan C Chaudhuri A Cornish K affil: McGill Child Laboratory for Research and Education in Developmental Disorders, McGill University, Montréal Canada sug: subj: Autism Spectrum Disorder Physiopathology Fragile X Syndrome Physiopathology Neural Pathways Genotype Autism Spectrum Disorder Familial and Genetic Fragile X Syndrome Familial and Genetic Conceptual Framework ab: We have previously described (see companion paper, this issue) the utility of using perceptual signatures for defining and dissociating condition-specific neural functioning underlying early visual processes in autism and FXS. These perceptually-driven hypotheses are based on differential performance evidenced only at the earliest stages of visual information processing, mediated by local neural network functioning. In this paper, we first review how most large-scale neural models are unable to address atypical low-level perceptual functioning in autism, and then suggest how condition-specific, local neural endophenotypes (described in our companion paper) can be incorporated into causal models to infer target candidate gene or gene clusters that are implicated in autism's pathogenesis. The usefulness of such a translational research approach is discussed. pubtype: Academic Journal doctype: tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|