Association between bone turnover, micronutrient intake, and blood lead levels in pre- and postmenopausal women, NHANES 1999-2002.
Background: Blood lead levels (BLLs) have been shown to increase during periods of high bone turnover such as pregnancy and menopause. Objectives: We examined the associations between bone turnover and micronutrient intake with BLLs in women 20DS85 years of age (n = 2,671) participating in the Natio...
| Publicado en: | Environmental Health Perspectives Vol. 118; no. 11; pp. 1590 - 1597 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Nov2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104964454&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104964454 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Nov2010 vid: 118 iid: 11 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104964454 2010879778 10.1289/ehp.1002158 NLM20688594 104964454 ppf: 1590 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Association between bone turnover, micronutrient intake, and blood lead levels in pre- and postmenopausal women, NHANES 1999-2002. aug: au: Jackson, Leila W. Cromer, Barbara A. Panneerselvamm, Ashok affil: Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA sug: subj: Bone Resorption Energy Intake Evaluation Lead Blood Micronutrients Postmenopause Premenopause Adult Aged Aged, 80 and Over Calcium Administration and Dosage Confidence Intervals Data Analysis Software Data Analysis, Statistical Descriptive Statistics Female Funding Source Human Iron Administration and Dosage Kruskal-Wallis Test Linear Regression Middle Age P-Value Self Report Vitamin D Administration and Dosage Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female ab: Background: Blood lead levels (BLLs) have been shown to increase during periods of high bone turnover such as pregnancy and menopause. Objectives: We examined the associations between bone turnover and micronutrient intake with BLLs in women 20DS85 years of age (n = 2,671) participating in the National Health and Nutrition Examination Survey, 1999DS2002. Methods: Serum bone-specific alkaline phosphatase (BAP) and urinary cross-linked N-telopeptides (NTx) were measured as markers of bone formation and resorption, respectively. Lead was quantified in whole blood. The association between tertiles of BAP and NTx, and BLLs was examined using linear regression with natural log-transformed BLLs as the dependent variable and interpreted as the percent difference in geometric mean BLLs. Results: In adjusted analyses, mean BLLs among postmenopausal women in the upper tertiles of NTx and BAP were 34% [95% confidence interval (CI), 23%DS45%] and 30% (95% CI, 17%DS43%) higher than BLLs among women in the lowest tertiles of NTx and BAP, respectively. These associations were weaker, but remained statistically significant, among premenopausal women (NTx: 10%; 95% CI, 0.60%DS19%; BAP: 14%; 95% CI, 6%DS22%). Within tertiles of NTx and BAP, calcium intake above the Dietary Reference Intake (DRI), compared with below the DRI, was associated with lower mean BLLs among postmenopausal women but not premenopausal women, although most of the associations were not statistically significant. We observed similar associations for vitamin D supplement use. Conclusions: Bone resorption and bone formation were associated with a significant increase in BLLs among pre- and postmenopausal women. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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