A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects.
Background: Oxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects. Methods: The study population com...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 67; no. 1; pp. 19 - 24 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104972094&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104972094 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Jan2011 vid: 67 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104972094 56792763 10.1007/s00228-010-0941-z NLM21069518 104972094 ppf: 19 ppct: 5 formats: fmt: @attributes: type: P tig: atl: A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects. aug: au: Eskiizmir G Hirçin Z Özyurt B Ünlü H affil: Department of Otorhinolaryngology, Celal Bayar University, 45010 Manisa Turkey sug: subj: Oxymetazoline Pharmacodynamics Vasoconstrictor Agents, Nasal Pharmacodynamics Oxymetazoline Therapeutic Use Vasoconstrictor Agents, Nasal Therapeutic Use Airway Resistance Drug Effects Comparative Studies Human Rhinometry, Acoustic Kruskal-Wallis Test Mann-Whitney U Test Male Female Adult Manometry Methods Data Analysis Software Nasal Mucosa Drug Effects Nasal Obstruction Drug Therapy Oxymetazoline Administration and Dosage Vasoconstrictor Agents, Nasal Administration and Dosage Adult: 19-44 years Male Female ab: Background: Oxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects. Methods: The study population comprised thirty healthy adults. All subjects underwent active anterior rhinomanometry (AARhm) and acoustic rhinometry (AR) tests following the application of oxymetazoline, xylometazoline, or placebo (physiological saline). The change in nasal resistance, nasal airflow, and different cross-sectional areas (CSAs) of the nasal cavity in the subjects were examined for each solution separately. The measurements were obtained over a 1-h period (baseline and 1, 15, 30, and 60 min post-dosing). All results were analyzed using the Kruskal-Wallis test and the Mann-Whitney U test. Results: A total of 6,300 measurements of AARhm and AR were obtained. The application of placebo did not cause a statistically significant change in nasal resistance, nasal airflow, and CSAs (CSA1, 2, and 3, respectively) of the nasal cavity. In contrast, statistically significant changes in nasal resistance (inspiration p = 0.000 and p = 0.004; expiration p = 0.000 and p = 0.000), nasal airflow (inspiration p = 0.000 and p = 0.004; expiration p = 0.000 and p = 0.000), and CSAs of the nasal cavity (CSA2 p = 0.000 and p = 0.000, CSA3 p = 0.000 and p = 0.00), with the exception of CSA1 ( p = 0.982 and p = 0.994), were obtained after the application of oxymetazoline and xylometazoline. A comparison of oxymetazoline and xylometazoline based on nasal resistance, nasal airflow, and CSAs of the nasal cavity demonstrated no statistically significant difference, except for CSA3. Conclusion: Oxymetazoline and xylometazoline are fast-acting and potent topical decongestants that have similar decongestive effects. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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