Beyond genetics: epigenetic code in chronic kidney disease.
Epigenetics refers to a heritable change in the pattern of gene expression that is mediated by a mechanism specifically not due to alterations in the primary nucleotide sequence. Well-known epigenetic mechanisms encompass DNA methylation, chromatin remodeling (histone modifications), and RNA interfe...
| Publicado en: | Kidney International Vol. 79; no. 1; pp. 23 - 33 |
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| Autores principales: | , , , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Elsevier B.V.
Jan2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104977086&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104977086 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00852538 4CU jtl: Kidney International issn: 00852538 maglogo: N pubinfo: dt: Jan2011 vid: 79 iid: 1 pid: 82545 pub: Elsevier B.V. place: Philadelphia, Pennsylvania artinfo: ui: 104977086 NLM20881938 2010898250 10.1038/ki.2010.335 NLM20881938 PMC3867804 104977086 ppf: 23 ppct: 10 formats: tig: atl: Beyond genetics: epigenetic code in chronic kidney disease. aug: au: Dwivedi RS Herman JG McCaffrey TA Raj DS Dwivedi, Rama S Herman, James G McCaffrey, Timothy A Raj, Dominic S C affil: Division of Renal Diseases and Hypertension, The George Washington University, Washington, District of Columbia 20037, USA sug: subj: Genomics Trends Kidney Failure, Chronic Atherosclerosis DNA Diabetes Mellitus Drug Discovery Immunity Genes ab: Epigenetics refers to a heritable change in the pattern of gene expression that is mediated by a mechanism specifically not due to alterations in the primary nucleotide sequence. Well-known epigenetic mechanisms encompass DNA methylation, chromatin remodeling (histone modifications), and RNA interference. Functionally, epigenetics provides an extra layer of transcriptional control and plays a crucial role in normal physiological development, as well as in pathological conditions. Aberrant DNA methylation is implicated in immune dysfunction, inflammation, and insulin resistance. Epigenetic changes may be responsible for 'metabolic memory' and development of micro- and macrovascular complications of diabetes. MicroRNAs are critical in the maintenance of glomerular homeostasis and hence RNA interference may be important in the progression of renal disease. Recent studies have shown that epigenetic modifications orchestrate the epithelial-mesenchymal transition and eventually fibrosis of the renal tissue. Oxidative stress, inflammation, hyperhomocysteinemia, and uremic toxins could induce epimutations in chronic kidney disease. Epigenetic alterations are associated with inflammation and cardiovascular disease in patients with chronic kidney disease. Reversible nature of the epigenetic changes gives a unique opportunity to halt or even reverse the disease process through targeted therapeutic strategies. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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