Health related quality of life after extremely preterm birth.

Background: The majority of infants born before the last trimester now grow up. However, knowledge on subsequent health related quality of life (HRQoL) is scarce. We therefore aimed to compare HRQoL in children born extremely preterm with control children born at term. Furthermore, we assessed HRQoL...

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Publicado en:Neonatal Intensive Care Vol. 23; no. 7; pp. 35 - 41
Autores principales: Vederhus, Bente J., Markestad, Trond, Eide, Geir E., Graue, Marit, Halvorsen, Thomas
Formato: research Journal Article
Publicado: Goldstein & Associates 2010 Nov-Dec
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 2010 Nov-Dec
      vid: 23
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      pub: Goldstein & Associates
      place: Los Angeles, California
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        atl: Health related quality of life after extremely preterm birth.
      aug:
        au:
          Vederhus, Bente J.
          Markestad, Trond
          Eide, Geir E.
          Graue, Marit
          Halvorsen, Thomas
        affil: Department of Paediatrics, Haukeland University Hospital, Bergen
      sug:
        subj:
          Health Status In Infancy and Childhood
          Infant, Premature
          Quality of Life
          Birth Weight
          Coefficient alpha
          Comparative Studies
          Confidence Intervals
          Data Analysis Software
          Demography
          Descriptive Statistics
          Forced Expiratory Volume
          Gestational Age
          Human
          Infant Mortality
          Infant, Newborn
          Intensive Care Units, Neonatal
          Internal Consistency
          McNemar's Test
          Medical Records
          Norway
          Odds Ratio
          Paired T-Tests
          Power Analysis
          Questionnaires
          Record Review
          Regression
          Scales
          Socioeconomic Factors
          Summated Rating Scaling
          Infant, Newborn: birth-1 month
      ab: Background: The majority of infants born before the last trimester now grow up. However, knowledge on subsequent health related quality of life (HRQoL) is scarce. We therefore aimed to compare HRQoL in children born extremely preterm with control children born at term. Furthermore, we assessed HRQoL in relation to perinatal and neonatal morbidity and to current clinical and sociodemographic characteristics. Method: The Child Health Questionnaire (CHQ-PF50) and a general questionnaire were applied in a population based cohort of 10 year old children born at gestational age < or = 28 weeks or with birth weight < or = 1000 grams in Western Norway in 1991-92 and in term-born controls, individually matched for gender and time of birth. The McNemar test and paired t-tests were used to explore group differences between preterms and matched controls. Paired regression models and analyses of interaction (SPSS mixed linear model) were used to explore potential effects of sociodemographic and clinical characteristics on HRQoL in the two groups. Results: All 35 eligible preterm children participated. None had major impairments. Learning and/or attention problems were present in 71% of preterms and 20% of controls (odds ratio (OR): 7.0; 95% confidence interval (CI): 2.2 to 27.6). Insufficient professional support was described by 36% of preterm vs. 3% of control parents (OR: infinite; CI: 2.7 to infinite). Preterms scored lower on eight CHQ-PF50 sub-scales and the two summary scores, boys accounting for most of the deficits in areas of behavior, psychosocial functioning and parental burden. HRQoL was associated with learning and/or attention problems in both preterm and control children, significantly more so in preterms in areas related to health and parental burden. Within the preterm group, HRQoL was mostly unrelated to perinatal and neonatal morbidity. Conclusions: HRQoL for children born extremely preterm, and particularly for boys, was described by parents to be inferior to that of children born at term, and sufficiently poor to affect the dally life of the children and their families. Learning and/or attention problems were reported for a majority of preterms, strongly influencing their HRQoL.
      pubtype: Periodical
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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