Volumetric reduction in various cortical regions of elderly patients with early-onset and late-onset mania.
Background: Few studies have examined alterations of the brain in elderly bipolar patients. As late-onset mania is associated with increased cerebrovascular morbidity and neurological damage compared with typical/early-onset mania, we investigated differences in the volume of various cortical region...
| Publicado en: | International Psychogeriatrics Vol. 23; no. 1; pp. 149 - 155 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
02/01/2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104983837&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104983837 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10416102 RAF jtl: International Psychogeriatrics issn: 10416102 maglogo: N pubinfo: dt: 02/01/2011 vid: 23 iid: 1 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 104983837 NLM20561379 2010906143 10.1017/S1041610210000633 NLM20561379 104983837 ppf: 149 ppct: 6 formats: tig: atl: Volumetric reduction in various cortical regions of elderly patients with early-onset and late-onset mania. aug: au: Huang SH Tsai SY Hsu JL Huang YL Huang, Shou-Hung Tsai, Shang-Ying Hsu, Jung-Lung Huang, Yi-Lin affil: Department of Psychiatry and Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan sug: subj: Bipolar Disorder Cerebral Cortex Pathology Magnetic Resonance Imaging Age of Onset Aged Aged, 80 and Over Bipolar Disorder Diagnosis Bipolar Disorder Psychosocial Factors Basal Ganglia Pathology Female Frontal Lobe Pathology Limbic System Pathology Male Middle Age Body Weights and Measures Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Background: Few studies have examined alterations of the brain in elderly bipolar patients. As late-onset mania is associated with increased cerebrovascular morbidity and neurological damage compared with typical/early-onset mania, we investigated differences in the volume of various cortical regions between elderly patients with early-onset versus late-onset mania.Methods: We recruited 44 bipolar patients aged over 60 years, who underwent volumetric magnetic resonance imaging at 1.5 T. The analytic method is based on the hidden Markov random field model with an expectation-maximization algorithm. We determined the volume of each cortical region as a percentage of the total intracranial volume. The cutoff age for defining early versus late onset was 45 years.Results: The study participants consisted of 25 patients with early-onset mania and 19 patients with late-onset mania; their mean ages were 65.7 years and 62.8 years, respectively. The demographic variables of the two groups were comparable. The volumes of the left caudate nucleus (p = 0.022) and left middle frontal gyrus (p = 0.013) were significantly greater and that of the right posterior cingulate gyrus (p = 0.019) was significantly smaller in the late-onset group. More patients with late-onset mania had comorbid cerebrovascular disease (p = 0.072).Conclusions: The right posterior cingulate gyrus is smaller and the left caudate nucleus and left middle frontal gyrus are larger in patients with late-onset mania compared with those with early-onset mania. Volumetric change in brain regions may vary in elderly bipolar patients with early and late-onset mania. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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