Multiplicative model for assessment of chemical-induced cancer risk.
The multiplicative model for estimating incremental cancer risks linked with chemical-specific exposure is developed. The distinguishing feature of the model is that the additional cancer rate in the result of exposure to carcinogenic chemicals changes with age as a value proportional to the backgro...
| Publicado en: | International Journal of Environmental Health Research Vol. 21; no. 1; pp. 1 - 22 |
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| Autor principal: | |
| Formato: | equations & formulas tables/charts Journal Article |
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Taylor & Francis Ltd
Feb2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104986216&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104986216 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Feb2011 vid: 21 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104986216 57378963 10.1080/09603123.2010.499454 NLM21246430 104986216 ppf: 1 ppct: 21 formats: fmt: @attributes: type: P tig: atl: Multiplicative model for assessment of chemical-induced cancer risk. aug: au: Korobitsyn BA affil: Institute of Industrial Ecology, Ural Branch of Russian Academy of Sciences, Yekaterinburg, Russian Federation sug: subj: Risk Assessment Methods Models, Statistical Neoplasms Chemically Induced Neoplasms Risk Factors Carcinogens, Environmental Adverse Effects Environmental Exposure Adverse Effects Neoplasms Epidemiology United States Russia Neoplasms Epidemiology Neoplasms Etiology Longevity Age Factors United States Environmental Protection Agency ab: The multiplicative model for estimating incremental cancer risks linked with chemical-specific exposure is developed. The distinguishing feature of the model is that the additional cancer rate in the result of exposure to carcinogenic chemicals changes with age as a value proportional to the background cancer at this age. The proposed methodology enables assessing excess relative risk taking into account age and sex structure of background cancer rate in the exposed population, as well as the existence of a latent time between an exposure and an onset of disease. The model also enables estimating the environment pollution-related health damage, defined as the expected number of lost years of forthcoming life in the result of exposure. The model could be of value for the regulatory community and scientists in projecting a chemically-induced increase in cancer rate in one population to increases in cancer rates in other populations. pubtype: Academic Journal doctype: equations & formulas tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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