Inhibition of murine skin carcinogenesis by freeze-dried grape powder and other grape-derived major antioxidants.
Overexposure of the skin to carcinogenic insults causes a variety of adverse effects, among them the development of skin carcinomas. Since there is a need to develop efficient chemopreventive agents based on nutrition, our goal was to determine antioxidant and anti-carcinogenic properties of grapes...
| Publicado en: | Nutrition & Cancer Vol. 63; no. 1; pp. 28 - 39 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104986279&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104986279 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2011 vid: 63 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104986279 57379071 10.1080/01635581.2010.516474 NLM21108125 104986279 ppf: 28 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Inhibition of murine skin carcinogenesis by freeze-dried grape powder and other grape-derived major antioxidants. aug: au: Hanausek M Spears E Walaszek Z Kowalczyk MC Kowalczyk P Wendel C Slaga TJ affil: The University of Texas Health Science Center at San Antonio, Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA sug: subj: Skin Neoplasms Prevention and Control Fruit Antioxidants Animal Studies Mice Models, Biological Funding Source Fisher's Exact Test Chi Square Test Data Analysis Software One-Way Analysis of Variance ab: Overexposure of the skin to carcinogenic insults causes a variety of adverse effects, among them the development of skin carcinomas. Since there is a need to develop efficient chemopreventive agents based on nutrition, our goal was to determine antioxidant and anti-carcinogenic properties of grapes by evaluating grape powder developed by the California Table Grape Commission. In order to elucidate the mechanism(s) of action of grape powder, three of the major antioxidant components found in grapes-resveratrol, catechin, quercetin, and grape seed extract, containing a proanthocyanidin B-2-gallate-were evaluated for their abilities to inhibit oxidative stress and to protect the immune system. Tested antioxidants given topically and/or systemically strongly inhibited 7,12-dimethylbenz[a]anthracene (DMBA)-induced epidermal hyperplasia, proliferation, and inflammation. The hydroxylation of 2'-deoxyguanosine was markedly inhibited by topical and dietary administration of test variables, i.e., by approximately 40-70%. Simultaneous dietary and topical treatment with antioxidants reduced these biomarkers, showing strong additive and in some combinations synergistic effects. DMBA-mediated Ha-ras mutations in codon 61 were reduced by up to 50% with topical applications, but much higher inhibition was observed in mice treated with different combinations. The results of the present study clearly show impressive effects of combined topical and dietary treatments with above grape-derived antioxidants. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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