Computer-aided detection of intracranial aneurysms in mr angiography.

Intracranial aneurysms represent a significant cause of morbidity and mortality. While the risk factors for aneurysm formation are known, the detection of aneurysms remains challenging. Magnetic resonance angiography (MRA) has recently emerged as a useful non-invasive method for aneurysm detection....

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Publicado en:Journal of Digital Imaging Vol. 24; no. 1; pp. 86 - 96
Autores principales: Yang X, Blezek D, Cheng L, Ryan W, Kallmes D, Erickson B
Formato: equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Feb2011
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Feb2011
      vid: 24
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      pub: Springer Nature
      place: New York, New York
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        atl: Computer-aided detection of intracranial aneurysms in mr angiography.
      aug:
        au:
          Yang X
          Blezek D
          Cheng L
          Ryan W
          Kallmes D
          Erickson B
        affil: Mayo Clinic, Medical Imaging Informatics Innovation Center, Rochester USA
      sug:
        subj:
          Cerebral Aneurysm Diagnosis
          Magnetic Resonance Angiography
          Diagnosis, Computer Assisted
          Human
          Algorithms
          Sensitivity and Specificity
      ab: Intracranial aneurysms represent a significant cause of morbidity and mortality. While the risk factors for aneurysm formation are known, the detection of aneurysms remains challenging. Magnetic resonance angiography (MRA) has recently emerged as a useful non-invasive method for aneurysm detection. However, even for experienced neuroradiologists, the sensitivity to small (<5 mm) aneurysms in MRA images is poor, on the order of 30~60% in recent, large series. We describe a fully automated computer-aided detection (CAD) scheme for detecting aneurysms on 3D time-of-flight (TOF) MRA images. The scheme locates points of interest (POIs) on individual MRA datasets by combining two complementary techniques. The first technique segments the intracranial arteries automatically and finds POIs from the segmented vessels. The second technique identifies POIs directly from the raw, unsegmented image dataset. This latter technique is useful in cases of incomplete segmentation. Following a series of feature calculations, a small fraction of POIs are retained as candidate aneurysms from the collected POIs according to predetermined rules. The CAD scheme was evaluated on 287 datasets containing 147 aneurysms that were verified with digital subtraction angiography, the accepted standard of reference for aneurysm detection. For two different operating points, the CAD scheme achieved a sensitivity of 80% (71% for aneurysms less than 5 mm) with three mean false positives per case, and 95% (91% for aneurysms less than 5 mm) with nine mean false positives per case. In conclusion, the CAD scheme showed good accuracy and may have application in improving the sensitivity of aneurysm detection on MR images.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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