An ex vivo continuous passive motion model in a porcine knee for assessing primary stability of cell-free collagen gel plugs.
Background: Primary stability of cartilage repair constructs is of the utmost importance in the clinical setting but few continuous passive motion (CPM) models are available. Our study aimed to establish a novel ex vivo CPM animal model and to evaluate the required motion cycles for testing the mech...
| Publicado en: | BMC Musculoskeletal Disorders Vol. 11; pp. 283 - 284 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104994798&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104994798 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712474 1CI5 jtl: BMC Musculoskeletal Disorders issn: 14712474 maglogo: N pubinfo: dt: 2010 vid: 11 pid: 24147 pub: BioMed Central artinfo: ui: 104994798 NLM21159196 2010917564 10.1186/1471-2474-11-283 NLM21159196 PMC3019221 104994798 ppf: 283 ppct: 1 formats: tig: atl: An ex vivo continuous passive motion model in a porcine knee for assessing primary stability of cell-free collagen gel plugs. aug: au: Efe, Turgay Schofer, Markus D Füglein, Alexander Timmesfeld, Nina Fuchs-Winkelmann, Susanne Stein, Thomas El-Zayat, Bilal Farouk Paletta, Jürgen Rj Heyse, Thomas J affil: Department of Orthopedics and Rheumatology, University Hospital Marburg, Baldingerstrasse, 35043 Marburg, Germany. efet@med.uni-marburg.de. sug: subj: Collagen Gels Knee Joint Physiology Models, Biological Motion Therapy, Continuous Passive Methods Range of Motion Physiology Animal Studies Biomechanics Cartilage Diseases Therapy Motion Therapy, Continuous Passive Equipment and Supplies Swine Tissue Engineering Equipment and Supplies Tissue Engineering Methods ab: Background: Primary stability of cartilage repair constructs is of the utmost importance in the clinical setting but few continuous passive motion (CPM) models are available. Our study aimed to establish a novel ex vivo CPM animal model and to evaluate the required motion cycles for testing the mechanical properties of a new cell-free collagen type I gel plug (CaReS®-1S).Methods: A novel ex vivo CPM device was developed. Full-thickness cartilage defects (11 mm diameter by 6 mm deep) were created on the medial femoral condyle of porcine knee specimens. CaReS®-1S was implanted in 16 animals and each knee underwent continuous passive motion. After 0, 2000, 4000, 6000, and 8000 motions, standardized digital pictures of the grafts were taken, focusing on the worn surfaces. The percentage of worn surface on the total CaReS®-1S surface was evaluated with image processing software.Results: Significant differences in the worn surface were recorded between 0 and 2000 motion cycles (p < 0.0001). After 2000 motion cycles, there was no significant difference. No total delamination of CaReS®-1S with an empty defect site was recorded.Conclusion: The ex vivo CPM animal model is appropriate in investigating CaReS®-1S durability under continuous passive motion. 2000 motion cycles appear adequate to assess the primary stability of type I collagen gels used to repair focal chondral defects. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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