Leg length, skull circumference, and the prevalence of dementia in low and middle income countries: a 10/66 population-based cross sectional survey.
Background: Adult leg length is influenced by nutrition in the first few years of life. Adult head circumference is an indicator of brain growth. There is a limited literature linking short legs and small skulls to an increased risk for cognitive impairment and dementia in late life.Methods: One pha...
| Publicado en: | International Psychogeriatrics Vol. 23; no. 2; pp. 202 - 214 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
03/01/2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104995665&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104995665 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10416102 RAF jtl: International Psychogeriatrics issn: 10416102 maglogo: N pubinfo: dt: 03/01/2011 vid: 23 iid: 2 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 104995665 NLM20701817 2010919409 10.1017/S1041610210001274 NLM20701817 104995665 ppf: 202 ppct: 12 formats: tig: atl: Leg length, skull circumference, and the prevalence of dementia in low and middle income countries: a 10/66 population-based cross sectional survey. aug: au: Prince M Acosta D Dangour AD Uauy R Guerra M Huang Y Jacob KS Llibre Rodriguez JJ Salas A Sosa AL Williams JD Acosta I Albanese E Dewey ME Ferri CP Stewart R Gaona C Jotheeswaran AT Kumar PS Li S sug: subj: Dementia Pathology Leg Anatomy and Histology Skull Anatomy and Histology Aged Aged, 80 and Over Anthropometry China Cross Sectional Studies Cuba Dementia Diagnosis Dementia Epidemiology Developing Countries Dominican Republic Female Human India Male Mexico Nutritional Status Peru Prevalence Risk Factors Socioeconomic Factors Venezuela Aged: 65+ years Aged, 80 & over Female Male ab: Background: Adult leg length is influenced by nutrition in the first few years of life. Adult head circumference is an indicator of brain growth. There is a limited literature linking short legs and small skulls to an increased risk for cognitive impairment and dementia in late life.Methods: One phase cross-sectional surveys were carried out of all residents aged over 65 years in 11 catchment areas in China, India, Cuba, Dominican Republic, Venezuela, Mexico and Peru (n = 14,960). The cross-culturally validated 10/66 dementia diagnosis, and a sociodemographic and risk factor questionnaire were administered to all participants, and anthropometric measures taken. Poisson regression was used to calculate prevalence ratios for the effect of leg length and skull circumference upon 10/66 dementia, controlling for age, gender, education and family history of dementia.Results: The pooled meta-analyzed fixed effect for leg length (highest vs. lowest quarter) was 0.82 (95% CI, 0.68-0.98) and for skull circumference 0.75 (95% CI, 0.63-0.89). While point estimates varied between sites, the proportion of the variability attributable to heterogeneity between studies as opposed to sampling error (I2) was 0% for leg length and 22% for skull circumference. The effects were independent and not mediated by family history of dementia. The effect of skull circumference was not modified by educational level or gender, and the effect of leg length was not modified by gender.Conclusions: Since leg length and skull circumference are said to remain stable throughout adulthood into old age, reverse causality is an unlikely explanation for the findings. Early life nutritional programming, as well as neurodevelopment may protect against neurodegeneration. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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