Smaller brain size likely in young adults (<40 years old) with depressive symptoms compared to healthy controls: a retrospective study.
Purpose: The aim of this study was to determine whether the brain size of young patients with depressive symptoms is smaller than that of healthy controls using magnetic resonance imaging (MRI).Materials and Methods: We retrospectively evaluated brain size by calculating the ratio of the brain area...
| Publicado en: | Japanese Journal of Radiology Vol. 29; no. 1; pp. 19 - 25 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104996357&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104996357 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: Jan2011 vid: 29 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104996357 NLM21264657 2010920271 10.1007/s11604-010-0509-y NLM21264657 104996357 ppf: 19 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Smaller brain size likely in young adults (<40 years old) with depressive symptoms compared to healthy controls: a retrospective study. aug: au: Adachi M Shibata A Sato T Kawaguchi E Adachi, Michito Shibata, Akiko Sato, Takamichi Kawaguchi, Etsuko affil: Department of Radiology, Ohshima Clinic, Yamagata, 990-2321, Japan sug: subj: Brain Pathology Depression Magnetic Resonance Imaging Methods Adult Case Control Studies Telencephalon Pathology Female Human Male Retrospective Design Adult: 19-44 years Female Male ab: Purpose: The aim of this study was to determine whether the brain size of young patients with depressive symptoms is smaller than that of healthy controls using magnetic resonance imaging (MRI).Materials and Methods: We retrospectively evaluated brain size by calculating the ratio of the brain area to that of the skull (the brain-to-skull ratio) on routine MRI scans including the splenium of the corpus callosum obtained from 19 patients <40 years old with depressive symptoms in 2009. The controls were 12 healthy individuals <40 years old who underwent MRI for medical examinations.Results: The mean brain-to-skull ratio of the control group was 0.850 ± 0.022 (range 0.822-0.889), and that of the patient group was 0.819 ± 0.041 (range 0.756-0.878). An unpaired t-test showed a significant difference in the brain-to-skull ratios between these groups (P = 0.011). In particular, in 7 of the 19 patients with longer duration of illness and more severe symptoms, the brainto-skull ratio was 89%-92% of the mean ratio of the control group.Conclusion: The brain size of young patients with depressive symptoms appears to be smaller than that of healthy controls. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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